Oil-based adjuvants delivered intradermally induce high primary IgG2 immune response in swine
Jazyk angličtina Země Anglie, Velká Británie Médium print-electronic
Typ dokumentu časopisecké články
PubMed
28319826
DOI
10.1016/j.rvsc.2017.03.007
PII: S0034-5288(17)30047-4
Knihovny.cz E-zdroje
- Klíčová slova
- Adjuvant, Immunity, Intradermal, Th1/Th2, Vaccine,
- MeSH
- adjuvancia imunologická farmakologie MeSH
- antigeny aplikace a dávkování MeSH
- ELISA MeSH
- Freundovo adjuvans farmakologie MeSH
- hemokyanin farmakologie MeSH
- imunizace MeSH
- imunoglobulin G krev MeSH
- lidé MeSH
- lipidy farmakologie MeSH
- prasata * MeSH
- vakcinace veterinární MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- adjuvancia imunologická MeSH
- antigeny MeSH
- Freundovo adjuvans MeSH
- hemokyanin MeSH
- imunoglobulin G MeSH
- incomplete Freund's adjuvant MeSH Prohlížeč
- keyhole-limpet hemocyanin MeSH Prohlížeč
- lipidy MeSH
The effects of intradermal application of antigen with or without different adjuvants and activation of immune response are presented in this study. Six groups of six piglets each were immunized with keyhole limpet haemocyanin (KLH) antigen in combination with aluminium hydroxide or oil-based adjuvants (complete and incomplete Freund's adjuvants, Montanide ISA 206 and Emulsigen). IgG1 and IgG2 levels in sera were measured by KLH-specific ELISA. Interestingly, oil-based adjuvants induced high primary IgG2 response, suggesting the Th1 lymphocyte polarization. Also, considering the similarities between human and porcine organism, we suggest that intradermal application could be considered as an effective vaccine delivery route in both veterinary and human medicine.
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