Sex differences in the strategies of spatial learning in prenatally-exposed rats treated with various drugs in adulthood
Language English Country Netherlands Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
28359886
DOI
10.1016/j.bbr.2017.03.041
PII: S0166-4328(16)31091-9
Knihovny.cz E-resources
- Keywords
- Long-term drug treatment, Methamphetamine, Morris Water Maze, Sex differences, Spatial learning,
- MeSH
- Cognition drug effects MeSH
- Cocaine pharmacology MeSH
- Methamphetamine toxicity MeSH
- Morphine pharmacology MeSH
- N-Methyl-3,4-methylenedioxyamphetamine pharmacology MeSH
- Random Allocation MeSH
- Sex Characteristics * MeSH
- Rats, Wistar MeSH
- Spatial Navigation drug effects MeSH
- Spatial Learning drug effects MeSH
- Psychological Tests MeSH
- Psychotropic Drugs pharmacology MeSH
- Pregnancy MeSH
- Dronabinol pharmacology MeSH
- Prenatal Exposure Delayed Effects psychology MeSH
- Animals MeSH
- Check Tag
- Male MeSH
- Pregnancy MeSH
- Female MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Cocaine MeSH
- Methamphetamine MeSH
- Morphine MeSH
- N-Methyl-3,4-methylenedioxyamphetamine MeSH
- Psychotropic Drugs MeSH
- Dronabinol MeSH
In the present study we investigated the sex differences in the effect of adult long-term drug treatment on cognitive functions of Wistar rats, which were prenatally exposed to MA (5mg/kg) or saline. Cognitive functions were tested as an ability of spatial learning in the Morris Water Maze (MWM), which consisted of three types of tests: "Place Navigation Test"; "Probe Test", and "Memory Recall Test". Adult animals were injected daily, after completion of the last trial, either with saline or cocaine (COC; 5mg/kg), MDMA (3,4-methylenedioxy-methamphetamine; 5mg/kg), morphine (MOR; 5mg/kg), or delta-9-tetrahydrocannabinol (THC; 2mg/kg). Results revealed worsened MWM performance in female rats after drug treatment in adulthood. Not only were traditionally investigated parameters affected by drug treatment (latency of platform acquisition, search strategy, distance traveled), but also strategies used by animals (thigmotaxis, scanning). Analyses of search strategies observed in the Place Navigation Test, as well as in the Memory Recall Test, demonstrated variations in the percentage of time spent in thigmotaxis and scanning in females after treatment with COC, MDMA, MOR, and THC. Although we did not see a sensitizing effect of prenatal MA, in some cases the effect of drug treatment in adulthood differed depending on the prenatal drug exposure. The data presented in this study demonstrates that exposure to drugs with various mechanisms of action alters spatial abilities of female rats in the MWM. Alterations in the effect of adult drug treatment with reference to prenatal drug exposure were also found in the present study.
References provided by Crossref.org
An overview of the methamphetamine effect on male sexual behavior and reproductive system
The Impact of Neonatal Methamphetamine on Spatial Learning and Memory in Adult Female Rats
Early Postnatal Stress Impairs Cognitive Functions of Male Rats Persisting Until Adulthood
