Multipotency and therapeutic potential of NG2 cells
Language English Country Great Britain, England Media print-electronic
Document type Journal Article, Review, Research Support, Non-U.S. Gov't
PubMed
28522408
DOI
10.1016/j.bcp.2017.05.008
PII: S0006-2952(17)30258-7
Knihovny.cz E-resources
- Keywords
- Astrocytes, Glioma, Myelin plasticity, NG2 cells, Oligodendrocyte precursor cells (OPC),
- MeSH
- Antigens metabolism MeSH
- Stem Cells drug effects physiology MeSH
- Central Nervous System Agents pharmacology therapeutic use MeSH
- Humans MeSH
- Intercellular Signaling Peptides and Proteins metabolism MeSH
- Multipotent Stem Cells drug effects physiology transplantation MeSH
- Neurogenesis drug effects physiology MeSH
- Neuroglia drug effects physiology MeSH
- Neuronal Plasticity drug effects physiology MeSH
- Oligodendroglia drug effects physiology MeSH
- Cell Proliferation drug effects physiology MeSH
- Proteoglycans metabolism MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
- Names of Substances
- Antigens MeSH
- Central Nervous System Agents MeSH
- Intercellular Signaling Peptides and Proteins MeSH
- Proteoglycans MeSH
NG2 cells represent one of the most proliferative glial cell populations in the intact mammalian central nervous system (CNS). They are well-known for their ability to renew themselves or to generate new oligodendrocytes during development as well as in adulthood, therefore also being termed oligodendrocyte progenitor cells. Following CNS injuries, such as demyelination, trauma or ischemia, the proliferative capacity of NG2 cells rapidly increases and moreover, their differentiation potential broadens, as documented by numerous reports also describing their differentiation into astrocytes or even neurons. Here, we summarize the current knowledge about NG2 cells proliferation, their fate plasticity during embryogenesis as well as in postnatal CNS under physiological and pathological conditions, with the main emphasis on the role of various signaling molecules, growth factors, hormones or even neurotransmitters on the fate potential of NG2 cells.
References provided by Crossref.org
Out of the core: the impact of focal ischemia in regions beyond the penumbra
On the Common Journey of Neural Cells through Ischemic Brain Injury and Alzheimer's Disease