Semantic verbal fluency impairment is detectable in patients with subjective cognitive decline
Jazyk angličtina Země Spojené státy americké Médium print-electronic
Typ dokumentu časopisecké články
- Klíčová slova
- Alzheimer’s disease, elderly/aging, mild cognitive impairment, subjective cognitive decline, verbal fluency,
- MeSH
- analýza rozptylu MeSH
- kognitivní poruchy komplikace MeSH
- lidé středního věku MeSH
- lidé MeSH
- neuropsychologické testy MeSH
- poruchy řeči diagnóza etiologie MeSH
- retrospektivní studie MeSH
- sémantika * MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- verbální chování fyziologie MeSH
- Check Tag
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
Patients with subjective cognitive decline (SCD) are at higher risk for conversion to dementia due to Alzheimer's disease (AD). Semantic verbal fluency (SVF) seems to be impaired in the early stages of AD. The goal of the present study was to identify the discriminative potential of verbal fluency (VF) in patients with SCD to show if very early signs of cognitive decline may be detected in SCD. We examined 93 normal controls (NC) and 61 participants with SCD. Each participant was administered a comprehensive neuropsychological battery. All participants underwent tests of VF: phonemic verbal fluency (PVF), letters K and P and SVF (animals and vegetables categories). In addition to the total score, two 30-second intervals, and clustering and switching indices in SVF were evaluated. SCD generated fewer words in the total score and 30- to 60-second interval in vegetables category and they performed more switches in animals category. There was no significant difference between the SCD and the NC groups in all other VF measures. Quantitative measures of SVF (a decreased number of vegetables) as well as qualitative measures were detected in SCD group and could be considered as an early neuropsychological marker of subtle cognitive impairment.
b International Clinical Research Center St Anne's University Hospital Brno Brno Czech Republic
c National Institute of Mental Health Klecany Czech Republic
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