Strong antimicrobial activity of xanthohumol and other derivatives from hops (Humulus lupulus L.) on gut anaerobic bacteria
Jazyk angličtina Země Dánsko Médium print-electronic
Typ dokumentu časopisecké články
PubMed
28960474
DOI
10.1111/apm.12747
Knihovny.cz E-zdroje
- Klíčová slova
- Clostridium, Xanthohumol, anaerobic bacteria, gut,
- MeSH
- anaerobióza fyziologie MeSH
- antibakteriální látky izolace a purifikace farmakologie MeSH
- Bacteroides fragilis účinky léků růst a vývoj MeSH
- Clostridioides difficile účinky léků růst a vývoj patogenita MeSH
- Clostridium perfringens účinky léků růst a vývoj MeSH
- cyklohexeny izolace a purifikace farmakologie MeSH
- flavonoidy izolace a purifikace farmakologie MeSH
- Humulus chemie MeSH
- infekce spojené se zdravotní péčí mikrobiologie MeSH
- lidé MeSH
- mikrobiální testy citlivosti MeSH
- propiofenony izolace a purifikace farmakologie MeSH
- průjem mikrobiologie MeSH
- pseudomembranózní enterokolitida mikrobiologie MeSH
- rostlinné extrakty chemie MeSH
- symbióza fyziologie MeSH
- terpeny izolace a purifikace farmakologie MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- antibakteriální látky MeSH
- cyklohexeny MeSH
- flavonoidy MeSH
- humulon MeSH Prohlížeč
- lupulon MeSH Prohlížeč
- propiofenony MeSH
- rostlinné extrakty MeSH
- terpeny MeSH
- xanthohumol MeSH Prohlížeč
Anaerobic bacteria, such as Bacteroides fragilis or Clostridium perfringens, are part of indigenous human flora. However, Clostridium difficile represents also an important causative agent of nosocomial infectious antibiotic-associated diarrhoea. Treatment of C. difficile infection is problematic, making it imperative to search for new compounds with antimicrobial properties. Hops (Humulus lupulus L.) contain substances with antibacterial properties. We tested antimicrobial activity of purified hop constituents humulone, lupulone and xanthohumol against anaerobic bacteria. The antimicrobial activity was established against B. fragilis, C. perfringens and C. difficile strains according to standard testing protocols (CLSI, EUCAST), and the minimum inhibitory concentrations (MICs) and minimum bactericidal concentrations (MBC) were calculated. All C. difficile strains were toxigenic and clinically relevant, as they were isolated from patients with diarrhoea. Strongest antimicrobial effects were observed with xanthohumol showing MIC and MBC values of 15-107 μg/mL, which are close to those of conventional antibiotics in the strains of bacteria with increased resistance. Slightly higher MIC and MBC values were obtained with lupulone followed by higher values of humulone. Our study, thus, shows a potential of purified hop compounds, especially xanthohumol, as alternatives for treatment of infections caused by select anaerobic bacteria, namely nosocomial diarrhoea caused by resistant strains.
Faculty of Military Medical Sciences University of Defence Hradec Kralove Czech Republic
Faculty of Pharmacy Charles University Hradec Králové Czech Republic
Institute of Microbiology Czech Academy of Sciences Prague 4 Czech Republic
Research Institute of Brewing and Malting PLC Prague Czech Republic
Citace poskytuje Crossref.org
