Mammalian zygotic genome activation
Language English Country Great Britain, England Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't, Review
PubMed
29233752
DOI
10.1016/j.semcdb.2017.12.006
PII: S1084-9521(17)30056-3
Knihovny.cz E-resources
- Keywords
- Chromatin, DNA methylation, Epigenetics, Gene expression, Histone modifications, Oocyte-to-embryo transition, Protamine/histone exchange, Retrotransponsons, Transcription, Zygotic genome activation,
- MeSH
- Embryo, Mammalian cytology MeSH
- Fertilization genetics MeSH
- Humans MeSH
- Oocytes cytology MeSH
- Mammals MeSH
- Gene Expression Regulation, Developmental genetics MeSH
- Animals MeSH
- Zygote cytology MeSH
- Check Tag
- Humans MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
Zygotic genome activation (ZGA) denotes the initiation of gene expression after fertilization. It is part of the complex oocyte-to-embryo transition (OET) in which a highly specialized cell - the oocyte - is fertilized and transformed into a zygote that gives rise to an embryo that will develop into a newborn. From the perspective of gene expression, the OET reflects reprogramming of germ cell gene expression into the new developmental program of the zygote. This reprogramming occurs at transcriptional and post-transcriptional levels. This review will discuss selected aspects of mammalian ZGA, highlighting shared features and evolved differences observed in commonly investigated mammals and non-mammalian model animals.
References provided by Crossref.org
The translational oscillation in oocyte and early embryo development
CHK1-CDC25A-CDK1 regulate cell cycle progression and protect genome integrity in early mouse embryos
Checkpoint Kinase 1 Is a Key Signal Transducer of DNA Damage in the Early Mammalian Cleavage Embryo
Nursing Exposure to Bisphenols as a Cause of Male Idiopathic Infertility
