The role of obesity and adipose tissue dysfunction in gestational diabetes mellitus
Language English Country England, Great Britain Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't, Review
PubMed
29743342
DOI
10.1530/joe-18-0032
PII: JOE-18-0032
Knihovny.cz E-resources
- Keywords
- adipokines, adipose tissue, gestational diabetes mellitus, inflammation, obesity,
- MeSH
- Adipokines physiology MeSH
- Diabetes, Gestational etiology physiopathology MeSH
- Insulin Resistance physiology MeSH
- Humans MeSH
- Obesity complications pathology physiopathology therapy MeSH
- Pregnancy MeSH
- Adipose Tissue pathology physiopathology MeSH
- Inflammation complications metabolism MeSH
- Check Tag
- Humans MeSH
- Pregnancy MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
- Names of Substances
- Adipokines MeSH
Gestational diabetes mellitus is defined as diabetes diagnosed in the second or third trimester of pregnancy in patients with no history of diabetes prior to gestation. It is the most common complication of pregnancy. The underlying pathophysiology shares some common features with type 2 diabetes mellitus (T2DM) combining relatively insufficient insulin secretion with increased peripheral insulin resistance. While a certain degree of insulin resistance is the physiological characteristics of the second half of pregnancy, it is significantly more pronounced in patients with gestational diabetes. Adipose tissue dysfunction and subclinical inflammation in obesity are well-described causes of increased insulin resistance in non-pregnant subjects and are often observed in individuals with T2DM. Emerging evidence of altered adipokine expression and local inflammation in adipose tissue in patients with gestational diabetes suggests an important involvement of adipose tissue in its etiopathogenesis. This review aims to summarize current knowledge of adipose tissue dysfunction and its role in the development of gestational diabetes. We specifically focus on the significance of alterations of adipokines and immunocompetent cells number and phenotype in fat. Detailed understanding of the role of adipose tissue in gestational diabetes may provide new insights into its pathophysiology and open new possibilities of its prevention and treatment.
References provided by Crossref.org
Adipokine Levels of RBP4, Resistin and Nesfatin-1 in Women Diagnosed With Gestational Diabetes
Circulating levels of selected adipokines in women with gestational diabetes and type 2 diabetes
