The role of obesity and adipose tissue dysfunction in gestational diabetes mellitus
Jazyk angličtina Země Anglie, Velká Británie Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem, přehledy
PubMed
29743342
DOI
10.1530/joe-18-0032
PII: JOE-18-0032
Knihovny.cz E-zdroje
- Klíčová slova
- adipokines, adipose tissue, gestational diabetes mellitus, inflammation, obesity,
- MeSH
- adipokiny fyziologie MeSH
- gestační diabetes etiologie patofyziologie MeSH
- inzulinová rezistence fyziologie MeSH
- lidé MeSH
- obezita komplikace patologie patofyziologie terapie MeSH
- těhotenství MeSH
- tuková tkáň patologie patofyziologie MeSH
- zánět komplikace metabolismus MeSH
- Check Tag
- lidé MeSH
- těhotenství MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- přehledy MeSH
- Názvy látek
- adipokiny MeSH
Gestational diabetes mellitus is defined as diabetes diagnosed in the second or third trimester of pregnancy in patients with no history of diabetes prior to gestation. It is the most common complication of pregnancy. The underlying pathophysiology shares some common features with type 2 diabetes mellitus (T2DM) combining relatively insufficient insulin secretion with increased peripheral insulin resistance. While a certain degree of insulin resistance is the physiological characteristics of the second half of pregnancy, it is significantly more pronounced in patients with gestational diabetes. Adipose tissue dysfunction and subclinical inflammation in obesity are well-described causes of increased insulin resistance in non-pregnant subjects and are often observed in individuals with T2DM. Emerging evidence of altered adipokine expression and local inflammation in adipose tissue in patients with gestational diabetes suggests an important involvement of adipose tissue in its etiopathogenesis. This review aims to summarize current knowledge of adipose tissue dysfunction and its role in the development of gestational diabetes. We specifically focus on the significance of alterations of adipokines and immunocompetent cells number and phenotype in fat. Detailed understanding of the role of adipose tissue in gestational diabetes may provide new insights into its pathophysiology and open new possibilities of its prevention and treatment.
Citace poskytuje Crossref.org
Adipokine Levels of RBP4, Resistin and Nesfatin-1 in Women Diagnosed With Gestational Diabetes
Circulating levels of selected adipokines in women with gestational diabetes and type 2 diabetes
