Effects of β-glucan and Vitamin D Supplementation on Inflammatory Parameters in Patients with Diabetic Retinopathy
Jazyk angličtina Země Velká Británie, Anglie Médium print-electronic
Typ dokumentu klinické zkoušky kontrolované, časopisecké články
- Klíčová slova
- CRP, IL-6, beta-glucan, leptin, vitamin D,
- MeSH
- beta-glukany aplikace a dávkování MeSH
- C-reaktivní protein analýza MeSH
- diabetická retinopatie komplikace farmakoterapie patofyziologie MeSH
- index tělesné hmotnosti MeSH
- interleukin-6 krev MeSH
- leptin krev MeSH
- lidé středního věku MeSH
- lidé MeSH
- nedostatek vitaminu D komplikace farmakoterapie MeSH
- placebo MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- sérový amyloid A analýza MeSH
- vitamin D aplikace a dávkování krev MeSH
- zánět farmakoterapie MeSH
- Check Tag
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- klinické zkoušky kontrolované MeSH
- Geografické názvy
- Česká republika MeSH
- Názvy látek
- beta-glukany MeSH
- C-reaktivní protein MeSH
- interleukin-6 MeSH
- leptin MeSH
- placebo MeSH
- sérový amyloid A MeSH
- vitamin D MeSH
The objective of this article is to evaluate the potential effects of beta-glucan and vitamin D supplementation in patients with diabetic retinopathy. We evaluated the levels of several parameters of inflammatory reactions (C-reactive protein [CRP], serum amyloid A [SAA], and interleukin- [IL-] 6), leptin, and vitamin D. Using a 3-month interval, we divided the patients into three groups: (1) supplemented with beta-glucan and vitamin D, (2) supplemented with vitamin D and placebo, and (3) supplemented with vitamin D alone. By this division, we aim not only to observe whether beta-glucan can increase the effects of vitamin D, but also to eliminate the potential effects of placebo. The doses of vitamin D corresponded to phototype, weight, age, and sex of the individual. Fifty-two diabetic retinopathy patients were selected for our study. We found significant vitamin D deficits in all cases, even after three months of supplementation with vitamin D. Significant changes in levels of CRP were observed in the beta-glucan-supplemented group; levels of SAA and IL-6 were not changed. Leptin levels were significantly lowered in the beta-glucan-supplemented group and increased in the other groups. More detailed studies and/or longer supplementation is necessary.
b Eye Clinic UJEP Masaryk Hospital Krajská zdravotní a s Usti nad Labem Czech Republic
c University of Louisville Department of Pathology Louisville KY USA
Institute of Health located in Ústí nad Labem Usti nad Labem Czech Republic
Citace poskytuje Crossref.org
Diabetic macular edema treatment with subthreshold micropulse laser - five-year long monitoring
Beta Glucan: Supplement or Drug? From Laboratory to Clinical Trials
