Effects of β-glucan and Vitamin D Supplementation on Inflammatory Parameters in Patients with Diabetic Retinopathy
Language English Country Great Britain, England Media print-electronic
Document type Controlled Clinical Trial, Journal Article
- Keywords
- CRP, IL-6, beta-glucan, leptin, vitamin D,
- MeSH
- beta-Glucans administration & dosage MeSH
- C-Reactive Protein analysis MeSH
- Diabetic Retinopathy complications drug therapy physiopathology MeSH
- Body Mass Index MeSH
- Interleukin-6 blood MeSH
- Leptin blood MeSH
- Middle Aged MeSH
- Humans MeSH
- Vitamin D Deficiency complications drug therapy MeSH
- Placebos MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Serum Amyloid A Protein analysis MeSH
- Vitamin D administration & dosage blood MeSH
- Inflammation drug therapy MeSH
- Check Tag
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Controlled Clinical Trial MeSH
- Geographicals
- Czech Republic MeSH
- Names of Substances
- beta-Glucans MeSH
- C-Reactive Protein MeSH
- Interleukin-6 MeSH
- Leptin MeSH
- Placebos MeSH
- Serum Amyloid A Protein MeSH
- Vitamin D MeSH
The objective of this article is to evaluate the potential effects of beta-glucan and vitamin D supplementation in patients with diabetic retinopathy. We evaluated the levels of several parameters of inflammatory reactions (C-reactive protein [CRP], serum amyloid A [SAA], and interleukin- [IL-] 6), leptin, and vitamin D. Using a 3-month interval, we divided the patients into three groups: (1) supplemented with beta-glucan and vitamin D, (2) supplemented with vitamin D and placebo, and (3) supplemented with vitamin D alone. By this division, we aim not only to observe whether beta-glucan can increase the effects of vitamin D, but also to eliminate the potential effects of placebo. The doses of vitamin D corresponded to phototype, weight, age, and sex of the individual. Fifty-two diabetic retinopathy patients were selected for our study. We found significant vitamin D deficits in all cases, even after three months of supplementation with vitamin D. Significant changes in levels of CRP were observed in the beta-glucan-supplemented group; levels of SAA and IL-6 were not changed. Leptin levels were significantly lowered in the beta-glucan-supplemented group and increased in the other groups. More detailed studies and/or longer supplementation is necessary.
b Eye Clinic UJEP Masaryk Hospital Krajská zdravotní a s Usti nad Labem Czech Republic
c University of Louisville Department of Pathology Louisville KY USA
Institute of Health located in Ústí nad Labem Usti nad Labem Czech Republic
References provided by Crossref.org
Diabetic macular edema treatment with subthreshold micropulse laser - five-year long monitoring
Beta Glucan: Supplement or Drug? From Laboratory to Clinical Trials
