Cells in the Non-Uniform Magnetic World: How Cells Respond to High-Gradient Magnetic Fields
Language English Country United States Media print-electronic
Document type Journal Article, Review
- Keywords
- cell differentiation, cell fate, cell signaling, intracellular forces, magnetic fields, magnetic gradient,
- MeSH
- Biological Evolution MeSH
- Cell Differentiation MeSH
- Cell Death physiology MeSH
- Time Factors MeSH
- Cytoskeleton physiology MeSH
- Stem Cells MeSH
- Humans MeSH
- Magnetic Fields * adverse effects MeSH
- Magnetics methods MeSH
- Membrane Potentials MeSH
- Neoplasms pathology MeSH
- Gene Expression Regulation MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Review MeSH
Imagine cells that live in a high-gradient magnetic field (HGMF). Through what mechanisms do the cells sense a non-uniform magnetic field and how such a field changes the cell fate? We show that magnetic forces generated by HGMFs can be comparable to intracellular forces and therefore may be capable of altering the functionality of an individual cell and tissues in unprecedented ways. We identify the cellular effectors of such fields and propose novel routes in cell biology predicting new biological effects such as magnetic control of cell-to-cell communication and vesicle transport, magnetic control of intracellular ROS levels, magnetically induced differentiation of stem cells, magnetically assisted cell division, or prevention of cells from dividing. On the basis of experimental facts and theoretical modeling we reveal timescales of cellular responses to high-gradient magnetic fields and suggest an explicit dependence of the cell response time on the magnitude of the magnetic field gradient.
References provided by Crossref.org
Effects of gradient high-field static magnetic fields on diabetic mice
Gradient Magnetic Field Accelerates Division of E. coli Nissle 1917
Effects of High Magnetic Fields on the Diffusion of Biologically Active Molecules
