Meeting report: 31st International Conference on Antiviral Research
Jazyk angličtina Země Nizozemsko Médium print-electronic
Typ dokumentu kongresy
PubMed
30086336
PubMed Central
PMC7113893
DOI
10.1016/j.antiviral.2018.08.002
PII: S0166-3542(18)30461-3
Knihovny.cz E-zdroje
- MeSH
- antivirové látky farmakologie terapeutické užití MeSH
- lidé MeSH
- objevování léků MeSH
- odměny a ceny MeSH
- výzkum MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- kongresy MeSH
- Geografické názvy
- Portugalsko MeSH
- Názvy látek
- antivirové látky MeSH
The 31st International Conference on Antiviral Research (ICAR) was held in Porto, Portugal from June 11-15, 2018. In this report, volunteer rapporteurs provide their summaries of scientific presentations, hoping to effectively convey the speakers' goals and the results and conclusions of their talks. This report provides an overview of the invited keynote and award lectures and highlights of short oral presentations, from the perspective of experts in antiviral research. Of note, a session on human cytomegalovirus included an update on the introduction to the clinic of letermovir for the prevention of CMV infection and disease. The 31st ICAR successfully promoted new discoveries in antiviral research and drug development. The 32nd ICAR will be held in Baltimore, Maryland, USA, May 6-10, 2019.
Cancer Research Centre of Lyon INSERM U1052 UMR_5286 CNRS University of Lyon Lyon France
Drake University College of Pharmacy and Health Sciences Des Moines IA USA
Institute for Antiviral Research Utah State University Logan UT USA
Zobrazit více v PubMed
Andrei G., Carter K., Janeba Z., Sampath A., Schang L.M., Tarbet E.B., Vere Hodge R.A., Bray M., Este J.A. Highlights of the 30th international conference on antiviral research. Antivir. Res. 2017;145:184–196. PubMed PMC
Archin N.M., Liberty A.L., Kashuba A.D., Choudhary S.K., Kuruc J.D., Crooks A.M., Parker D.C., Anderson E.M., Kearney M.F., Strain M.C., Richman D.D., Hudgens M.G., Bosch R.J., Coffin J.M., Eron J.J., Hazuda D.J., Margolis D.M. Administration of vorinostat disrupts HIV-1 latency in patients on antiretroviral therapy. Nature. 2012;487:482–485. PubMed PMC
Badia R., Pujantell M., Riveira-Muñoz E., Puig T., Torres-Torronteras J., Martí R., Clotet B., Ampudia R.M., Vives-Pi M., Esté J.A., Ballana E. The G1/S specific cyclin D2 is a regulator of HIV-1 restriction in non-proliferating cells. PLoS Pathog. 2016;12 1005810.1001371/journal.ppat.1005829. PubMed PMC
Badia R., Pujantell M., Torres-Torronteras J., Menendez-Arias L., Marti R., Ruzo A., Pauls E., Clotet B., Ballana E., Este J.A., Riveira-Munoz E. SAMHD1 is active in cycling cells permissive to HIV-1 infection. Antivir. Res. 2017;142:123–135. PubMed
Ballana E., Este J.A. SAMHD1: at the crossroads of cell proliferation, immune responses, and virus restriction. Trends Microbiol. 2015;23:680–692. PubMed
Berke J.M., Dehertogh P., Vergauwen K., Van Damme E., Mostmans W., Vandyck K., Pauwels F. Capsid assembly modulators have a dual mechanism of action in primary human hepatocytes infected with hepatitis B virus. Antimicrob. Agents Chemother. 2017;61 pii: e00560-00517. PubMed PMC
Carette J.E., Raaben M., Wong A.C., Herbert A.S., Obernosterer G., Mulherkar N., Kuehne A.I., Kranzusch P.J., Griffin A.M., Ruthel G., Dal Cin P., Dye J.M., Whelan S.P., Chandran K., Brummelkamp T.R. Ebola virus entry requires the cholesterol transporter Niemann-Pick C1. Nature. 2011;477:340–343. PubMed PMC
Chang J., Warren T.K., Zhao X., Gill T., Guo F., Wang L., Comunale M.A., Du Y., Alonzi D.S., Yu W., Ye H., Liu F., Guo J.T., Mehta A., Cuconati A., Butters T.D., Bavari S., Xu X., Block T.M. Small molecule inhibitors of ER alpha-glucosidases are active against multiple hemorrhagic fever viruses. Antivir. Res. 2013;98:432–440. PubMed PMC
Cromm P.M., Crews C.M. Targeted protein degradation: from chemical biology to drug discovery. Cell Chem. Biol. 2017;24:1181–1190. PubMed PMC
Decorsière A., Mueller H., van Breugel P.C., Abdul F., Gerossier L., Beran R.K., Livingston C.M., Niu C., Fletcher S.P., Hantz O., Strubin M. Hepatitis B virus X protein identifies the Smc5/6 complex as a host restriction factor. Nature. 2016;531:386. PubMed
Dion S., Bourgine M., Godon O., Levillayer F., Michel M.L. Adeno-associated virus-mediated gene transfer leads to persistent hepatitis B virus replication in mice expressing HLA-A2 and HLA-DR1 molecules. J. Virol. 2013;87:5554–5563. PubMed PMC
Dudas G., Carvalho L.M., Bedford T., Tatem A.J., Baele G., Faria N.R., Park D.J., Ladner J.T., Arias A., Asogun D., Bielejec F., Caddy S.L., Cotten M., D'Ambrozio J., Dellicour S., Di Caro A., Diclaro J.W., Duraffour S., Elmore M.J., Fakoli L.S., Faye O., Gilbert M.L., Gevao S.M., Gire S., Gladden-Young A., Gnirke A., Goba A., Grant D.S., Haagmans B.L., Hiscox J.A., Jah U., Kugelman J.R., Liu D., Lu J., Malboeuf C.M., Mate S., Matthews D.A., Matranga C.B., Meredith L.W., Qu J., Quick J., Pas S.D., Phan M.V.T., Pollakis G., Reusken C.B., Sanchez-Lockhart M., Schaffner S.F., Schieffelin J.S., Sealfon R.S., Simon-Loriere E., Smits S.L., Stoecker K., Thorne L., Tobin E.A., Vandi M.A., Watson S.J., West K., Whitmer S., Wiley M.R., Winnicki S.M., Wohl S., Wolfel R., Yozwiak N.L., Andersen K.G., Blyden S.O., Bolay F., Carroll M.W., Dahn B., Diallo B., Formenty P., Fraser C., Gao G.F., Garry R.F., Goodfellow I., Gunther S., Happi C.T., Holmes E.C., Kargbo B., Keita S., Kellam P., Koopmans M.P.G., Kuhn J.H., Loman N.J., Magassouba N., Naidoo D., Nichol S.T., Nyenswah T., Palacios G., Pybus O.G., Sabeti P.C., Sall A., Stroher U., Wurie I., Suchard M.A., Lemey P., Rambaut A. Virus genomes reveal factors that spread and sustained the Ebola epidemic. Nature. 2017;544:309–315. PubMed PMC
EASL EASL recommendations on treatment of hepatitis C 2018. J. Hepatol. 2018;69:461–511. PubMed
Edwards T.C., Lomonosova E., Patel J.A., Li Q., Villa J.A., Gupta A.K., Morrison L.A., Bailly F., Cotelle P., Giannakopoulou E., Zoidis G., Tavis J.E. Inhibition of hepatitis B virus replication by N-hydroxyisoquinolinediones and related polyoxygenated heterocycles. Antivir. Res. 2017;143:205–217. PubMed PMC
Faria N.R., Rambaut A., Suchard M.A., Baele G., Bedford T., Ward M.J., Tatem A.J., Sousa J.D., Arinaminpathy N., Pepin J., Posada D., Peeters M., Pybus O.G., Lemey P. HIV epidemiology. The early spread and epidemic ignition of HIV-1 in human populations. Science. 2014;346:56–61. PubMed PMC
Ferir G., Petrova M.I., Andrei G., Huskens D., Hoorelbeke B., Snoeck R., Vanderleyden J., Balzarini J., Bartoschek S., Bronstrup M., Sussmuth R.D., Schols D. The lantibiotic peptide labyrinthopeptin A1 demonstrates broad anti-HIV and anti-HSV activity with potential for microbicidal applications. PLoS One. 2013;8 PubMed PMC
Gollnest T., de Oliveira T.D., Schols D., Balzarini J., Meier C. Lipophilic prodrugs of nucleoside triphosphates as biochemical probes and potential antivirals. Nat. Commun. 2015;6:8716. PubMed PMC
Gollnest T., Dinis de Oliveira T., Rath A., Hauber I., Schols D., Balzarini J., Meier C. Membrane-permeable triphosphate prodrugs of nucleoside analogues. Angew Chem. Int. Ed. Engl. 2016;55:5255–5258. PubMed
Guo F., Wu S., Julander J., Ma J., Zhang X., Kulp J., Cuconati A., Block T.M., Du Y., Guo J.T., Chang J. A novel benzodiazepine compound inhibits yellow fever virus infection by specifically targeting NS4B protein. J. Virol. 2016;90:10774–10788. PubMed PMC
Huang L.R., Wohlleber D., Reisinger F., Jenne C.N., Cheng R.L., Abdullah Z., Schildberg F.A., Odenthal M., Dienes H.P., van Rooijen N., Schmitt E., Garbi N., Croft M., Kurts C., Kubes P., Protzer U., Heikenwalder M., Knolle P.A. Intrahepatic myeloid-cell aggregates enable local proliferation of CD8(+) T cells and successful immunotherapy against chronic viral liver infection. Nat. Immunol. 2013;14:574–583. PubMed
Ivanova L., Buch A., Dohner K., Pohlmann A., Binz A., Prank U., Sandbaumhuter M., Bauerfeind R., Sodeik B. Conserved tryptophan motifs in the large tegument protein pUL36 are required for efficient secondary envelopment of herpes simplex virus capsids. J. Virol. 2016;90:5368–5383. PubMed PMC
Komazin-Meredith G., Cardinale S.C., Comeau K., Magalhaes K.J., Hartline C.B., Williams J.D., Opperman T.J., Prichard M.N., Bowlin T.L. TAOK3 phosphorylates the methylenecyclopropane nucleoside MBX 2168 to its monophosphate. Antivir. Res. 2015;119:23–27. PubMed PMC
Lahaye X., Satoh T., Gentili M., Cerboni S., Conrad C., Hurbain I., El Marjou A., Lacabaratz C., Lelievre J.D., Manel N. The capsids of HIV-1 and HIV-2 determine immune detection of the viral cDNA by the innate sensor cGAS in dendritic cells. Immunity. 2013;39:1132–1142. PubMed
Lambert D.M., Barney S., Lambert A.L., Guthrie K., Medinas R., Davis D.E., Bucy T., Erickson J., Merutka G., Petteway S.R., Jr. Peptides from conserved regions of paramyxovirus fusion (F) proteins are potent inhibitors of viral fusion. Proc. Natl. Acad. Sci. U. S. A. 1996;93:2186–2191. PubMed PMC
Lan H., Tang Z., Jin H., Sun Y. Neddylation inhibitor MLN4924 suppresses growth and migration of human gastric cancer cells. Sci. Rep. 2016;6:24218. PubMed PMC
Liljeroos L., Krzyzaniak M.A., Helenius A., Butcher S.J. Architecture of respiratory syncytial virus revealed by electron cryotomography. Proc. Natl. Acad. Sci. U. S. A. 2013;110:11133–11138. PubMed PMC
Lomonosova E., Daw J., Garimallaprabhakaran A.K., Agyemang N.B., Ashani Y., Murelli R.P., Tavis J.E. Efficacy and cytotoxicity in cell culture of novel alpha-hydroxytropolone inhibitors of hepatitis B virus ribonuclease H. Antivir. Res. 2017;144:164–172. PubMed PMC
Ma J., Wu S., Zhang X., Guo F., Yang K., Guo J., Su Q., Lu H., Lam P., Li Y., Yan Z., Kinney W., Guo J.T., Block T.M., Chang J., Du Y. Ester prodrugs of IHVR-19029 with enhanced oral exposure and prevention of gastrointestinal glucosidase interaction. ACS Med. Chem. Lett. 2017;8:157–162. PubMed PMC
Martinez-Gualda B., Sun L., Rivero-Buceta E., Flores A., Quesada E., Balzarini J., Noppen S., Liekens S., Schols D., Neyts J., Leyssen P., Mirabelli C., Camarasa M.J., San-Felix A. Structure-activity relationship studies on a Trp dendrimer with dual activities against HIV and enterovirus A71. Modifications on the amino acid. Antivir. Res. 2017;139:32–40. PubMed
Marty F.M., Ljungman P., Chemaly R.F., Maertens J., Dadwal S.S., Duarte R.F., Haider S., Ullmann A.J., Katayama Y., Brown J., Mullane K.M., Boeckh M., Blumberg E.A., Einsele H., Snydman D.R., Kanda Y., DiNubile M.J., Teal V.L., Wan H., Murata Y., Kartsonis N.A., Leavitt R.Y., Badshah C. Letermovir prophylaxis for cytomegalovirus in hematopoietic-cell transplantation. N. Engl. J. Med. 2017;377:2433–2444. PubMed
Mehellou Y., Rattan H.S., Balzarini J. The ProTide prodrug technology: from the concept to the clinic. J. Med. Chem. 2018;61:2211–2226. PubMed PMC
Meier C. Nucleoside diphosphate and triphosphate prodrugs - an unsolvable task? Antivir. Chem. Chemother. 2017;25:69–82. PubMed PMC
Meier C., Balzarini J. Application of the cycloSal-prodrug approach for improving the biological potential of phosphorylated biomolecules. Antivir. Res. 2006;71:282–292. PubMed
Miller E.H., Obernosterer G., Raaben M., Herbert A.S., Deffieu M.S., Krishnan A., Ndungo E., Sandesara R.G., Carette J.E., Kuehne A.I., Ruthel G., Pfeffer S.R., Dye J.M., Whelan S.P., Brummelkamp T.R., Chandran K. Ebola virus entry requires the host-programmed recognition of an intracellular receptor. EMBO J. 2012;31:1947–1960. PubMed PMC
Oiknine-Djian E., Weisblum Y., Panet A., Wong H.N., Haynes R.K., Wolf D.G. The artemisinin derivative artemisone is a potent inhibitor of human cytomegalovirus replication. Antimicrob. Agents Chemother. 2018;62:13. e00288-00218. PubMed PMC
Pauls E., Badia R., Torres-Torronteras J., Ruiz A., Permanyer M., Riveira-Muñoz E., Clotet B., Marti R., Ballana E., Esté J.A. Palbociclib, a selective inhibitor of cyclin-dependent kinase4/6, blocks HIV-1 reverse transcription through the control of sterile [alpha] motif and HD domain-containing protein-1 activity. AIDS. 2014;28:2213–2222. PubMed
Pujantell M., Franco S., Galván-Femenía I., Badia R., Castellví M., Garcia-Vidal E., Clotet B., de Cid R., Tural C., Martínez M.A., Riveira-Muñoz E., Esté J.A., Ballana E. ADAR1 affects HCV infection by modulating innate immune response. Antivir. Res. 2018;156:116–127. PubMed
Pujantell M., Riveira-Muñoz E., Badia R., Castellví M., Garcia-Vidal E., Sirera G., Puig T., Ramirez C., Clotet B., Esté J.A., Ballana E. RNA editing by ADAR1 regulates innate and antiviral immune functions in primary macrophages. Sci. Rep. 2017;7:13339. PubMed PMC
Scaturro P., Cortese M., Chatel-Chaix L., Fischl W., Bartenschlager R. Dengue virus non-structural protein 1 modulates infectious particle production via interaction with the structural proteins. PLoS Pathog. 2015;11 PubMed PMC
Shapira M.Y., Resnick I.B., Chou S., Neumann A.U., Lurain N.S., Stamminger T., Caplan O., Saleh N., Efferth T., Marschall M., Wolf D.G. Artesunate as a potent antiviral agent in a patient with late drug-resistant cytomegalovirus infection after hematopoietic stem cell transplantation. Clin. Infect. Dis. 2008;46:1455–1457. PubMed
Slusarczyk M., Serpi M., Pertusati F. Phosphoramidates and phosphonamidates (ProTides) with antiviral activity. Antivir. Chem. Chemother. 2018;26 2040206618775243. PubMed PMC
Staring J., van den Hengel L.G., Raaben M., Blomen V.A., Carette J.E., Brummelkamp T.R. KREMEN1 is a host entry receptor for a major group of enteroviruses. Cell Host Microbe. 2018;23:636–643. e635. PubMed
Staring J., von Castelmur E., Blomen V.A., van den Hengel L.G., Brockmann M., Baggen J., Thibaut H.J., Nieuwenhuis J., Janssen H., van Kuppeveld F.J., Perrakis A., Carette J.E., Brummelkamp T.R. PLA2G16 represents a switch between entry and clearance of Picornaviridae. Nature. 2017;541:412–416. PubMed
Suchard M.A., Lemey P., Baele G., Ayres D.L., Drummond A.J., Rambaut A. Bayesian phylogenetic and phylodynamic data integration using BEAST 1.10. Virus Evol. 2018;4:vey016. PubMed PMC
Tan X., Chu C.K., Boudinot F.D. Development and optimization of anti-HIV nucleoside analogs and prodrugs: a review of their cellular pharmacology, structure-activity relationships and pharmacokinetics. Adv. Drug Deliv. Rev. 1999;39:117–151. PubMed
Vere Hodge R.A. vol. 100. 2013. pp. 276–285. (Meeting Report: 26th International Conference on Antiviral Research). Antiviral Research. PubMed PMC
Vere Hodge R.A. vol. 111. 2014. pp. 143–153. (Meeting Report: 27th International Conference on Antiviral Research, in Raleigh, NC, USA). Antiviral Research. PubMed PMC
Vere Hodge R.A. vol. 123. 2015. pp. 172–187. (Meeting Report: 28th International Conference on Antiviral Research in Rome, Italy). Antiviral Research. PubMed PMC
Vere Hodge R.A. vol. 137. 2017. pp. 23–40. (Meeting Report: 29th International Conference on Antiviral Research in La Jolla, CA, USA). Antiviral Research. PubMed PMC
Vu D.M., Mutai N., Heath C.J., Vulule J.M., Mutuku F.M., Ndenga B.A., LaBeaud A.D. Unrecognized dengue virus infections in children, Western Kenya, 2014-2015. Emerg. Infect. Dis. 2017;23:1915–1917. PubMed PMC
Wang J., Bardelli M., Espinosa D.A., Pedotti M., Ng T.S., Bianchi S., Simonelli L., Lim E.X.Y., Foglierini M., Zatta F., Jaconi S., Beltramello M., Cameroni E., Fibriansah G., Shi J., Barca T., Pagani I., Rubio A., Broccoli V., Vicenzi E., Graham V., Pullan S., Dowall S., Hewson R., Jurt S., Zerbe O., Stettler K., Lanzavecchia A., Sallusto F., Cavalli A., Harris E., Lok S.M., Varani L., Corti D. A human Bi-specific antibody against Zika virus with high therapeutic potential. Cell. 2017;171:229–241 e215. PubMed PMC
Weinschenk L., Schols D., Balzarini J., Meier C. Nucleoside diphosphate prodrugs: nonsymmetric DiPPro-nucleotides. J. Med. Chem. 2015;58:6114–6130. PubMed
Worobey M., Watts T.D., McKay R.A., Suchard M.A., Granade T., Teuwen D.E., Koblin B.A., Heneine W., Lemey P., Jaffe H.W. 1970s and 'Patient 0' HIV-1 genomes illuminate early HIV/AIDS history in North America. Nature. 2016;539:98–101. PubMed PMC
Wu G., Swanson M., Talla A., Graham D., Strizki J., Gorman D., Barnard R.J., Blair W., Sogaard O.S., Tolstrup M., Ostergaard L., Rasmussen T.A., Sekaly R.P., Archin N.M., Margolis D.M., Hazuda D.J., Howell B.J. HDAC inhibition induces HIV-1 protein and enables immune-based clearance following latency reversal. JCI Insight. 2017;2 doi: 10.1172/jci.insight.92901. PubMed DOI PMC
Meeting report: 32nd International Conference on Antiviral Research