Genomic imprinting mediates dosage compensation in a young plant XY system
Language English Country England, Great Britain Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
30104649
DOI
10.1038/s41477-018-0221-y
PII: 10.1038/s41477-018-0221-y
Knihovny.cz E-resources
- MeSH
- Chromosomes, Plant * MeSH
- Genomic Imprinting * MeSH
- Dosage Compensation, Genetic * MeSH
- Sex Chromosomes * MeSH
- Gene Expression Regulation, Plant genetics MeSH
- Silene genetics physiology MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
Sex chromosomes have repeatedly evolved from a pair of autosomes. Consequently, X and Y chromosomes initially have similar gene content, but ongoing Y degeneration leads to reduced expression and eventual loss of Y genes1. The resulting imbalance in gene expression between Y genes and the rest of the genome is expected to reduce male fitness, especially when protein networks have components from both autosomes and sex chromosomes. A diverse set of dosage compensating mechanisms that alleviates these negative effects has been described in animals2-4. However, the early steps in the evolution of dosage compensation remain unknown, and dosage compensation is poorly understood in plants5. Here, we describe a dosage compensation mechanism in the evolutionarily young XY sex determination system of the plant Silene latifolia. Genomic imprinting results in higher expression from the maternal X chromosome in both males and females. This compensates for reduced Y expression in males, but results in X overexpression in females and may be detrimental. It could represent a transient early stage in the evolution of dosage compensation. Our finding has striking resemblance to the first stage proposed by Ohno6 for the evolution of X inactivation in mammals.
Center for Bioinformatics in Rhônes Alpes Lyon France
Genetic Diversity Centre ETH Zurich Zurich Switzerland
Institute of Biophysics of the Czech Academy of Sciences Brno Czech Republic
Institute of Integrative Biology ETH Zurich Zurich Switzerland
Laboratoire Biométrie et Biologie Evolutive CNRS Université Lyon 1 Lyon France
References provided by Crossref.org
The Silene latifolia genome and its giant Y chromosome
Sexy ways: approaches to studying plant sex chromosomes
Dosage compensation evolution in plants: theories, controversies and mechanisms
Adaptive changes of the autosomal part of the genome in a dioecious clade of Silene
