Safety of Anti-TNF-Alpha Therapy During Pregnancy on Long-term Outcome of Exposed Children: A Controlled, Multicenter Observation
Jazyk angličtina Země Velká Británie, Anglie Médium print
Typ dokumentu časopisecké články, multicentrická studie, pozorovací studie, randomizované kontrolované studie, práce podpořená grantem
PubMed
30239799
DOI
10.1093/ibd/izy294
PII: 5104315
Knihovny.cz E-zdroje
- Klíčová slova
- anti-TNF-alpha, children, infections, inflammatory bowel disease, vaccination,
- MeSH
- adalimumab aplikace a dávkování MeSH
- dítě MeSH
- gastrointestinální látky aplikace a dávkování MeSH
- idiopatické střevní záněty farmakoterapie imunologie MeSH
- infliximab aplikace a dávkování MeSH
- kohortové studie MeSH
- kojenec MeSH
- komplikace těhotenství diagnóza farmakoterapie imunologie MeSH
- lidé MeSH
- matky MeSH
- následné studie MeSH
- předškolní dítě MeSH
- prognóza MeSH
- studie případů a kontrol MeSH
- těhotenství MeSH
- TNF-alfa antagonisté a inhibitory MeSH
- zpožděný efekt prenatální expozice farmakoterapie imunologie MeSH
- Check Tag
- dítě MeSH
- kojenec MeSH
- lidé MeSH
- mužské pohlaví MeSH
- předškolní dítě MeSH
- těhotenství MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- multicentrická studie MeSH
- pozorovací studie MeSH
- práce podpořená grantem MeSH
- randomizované kontrolované studie MeSH
- Názvy látek
- adalimumab MeSH
- gastrointestinální látky MeSH
- infliximab MeSH
- TNF-alfa MeSH
BACKGROUND: Evidence of the impact of in utero exposure to anti-tumor necrosis factor (TNF)-alpha on long-term childhood development is limited. The aim was to assess the impact of in utero exposure to anti-TNF-alpha due to mothers' inflammatory bowel disease (IBD) on long-term postnatal development of exposed children. METHODS: We included consecutive children (≥12 months of age) born to mothers with IBD (2007-2016) treated with anti-TNF-alpha during pregnancy in 3 centers in the Czech Republic. A control group was comprised of unexposed children of non-IBD mothers undergoing mandatory check-ups at general pediatricians' offices. Data on perinatal period, psychomotor development, vaccination, infections, antibiotics, and allergy were collected by treating pediatricians using a predefined questionnaire. RESULTS: Seventy-two exposed and 69 unexposed children were included (median age, 35 and 50 months, respectively). Exposed children had growth and psychomotor development similar to controls. There was no significant difference in infectious complications within the first year of life (23.9% vs 17.4%; P = 0.36) or during the whole follow-up between exposed infants and controls (P = 0.32). Concomitant immunosuppressants during pregnancy and anti-TNF-alpha levels in cord blood were not associated with elevated infection rate within the first year of life (P > 0.05). Over 95% of exposed children had adequate serologic response to vaccination, except for haemophilus and mumps vaccines. Clinically manifested allergy was similar between the groups (P = 0.98). CONCLUSIONS: Anti-TNF-alpha exposure in utero does not seem to have a negative impact on postnatal development of children with regard to infectious complications, allergy, growth, or psychomotor development when compared with unexposed children of non-IBD women.
Department of Internal Medicine Thomayer University Hospital Prague Czech Republic
Department of Internal Medicine University Hospital Plzeň Plzeň Czech Republic
IBD Clinical and Research Center ISCARE IVF a s Prague Czech Republic
Institute of Pharmacology 1st Faculty of Medicine Charles University Prague Czech Republic
Citace poskytuje Crossref.org
