Silver Fir (Abies alba) Extracts Inhibit Enzymes Involved in Blood Glucose Management and Protect against Oxidative Stress in High Glucose Environment
Jazyk angličtina Země Nizozemsko Médium print
Typ dokumentu časopisecké články
Grantová podpora
P4-0127
Javna Agencija za Raziskovalno Dejavnost RS
PubMed
30361961
DOI
10.1007/s11130-018-0698-6
PII: 10.1007/s11130-018-0698-6
Knihovny.cz E-zdroje
- Klíčová slova
- Diabetes, Digestive enzymes, Lignans, Oxidative stress, Silver fir,
- MeSH
- alfa-amylasy antagonisté a inhibitory MeSH
- alfa-glukosidasy metabolismus MeSH
- buněčné linie MeSH
- dipeptidylpeptidasa 4 metabolismus MeSH
- dřevo chemie MeSH
- hypoglykemika izolace a purifikace farmakologie MeSH
- inhibitory dipeptidylpeptidasy 4 izolace a purifikace farmakologie MeSH
- inhibitory glykosidových hydrolas izolace a purifikace farmakologie MeSH
- jedle chemie MeSH
- krevní glukóza účinky léků MeSH
- kůra rostlin chemie MeSH
- lidé MeSH
- myši MeSH
- oxidační stres účinky léků MeSH
- rostlinné extrakty izolace a purifikace farmakologie MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- myši MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- alfa-amylasy MeSH
- alfa-glukosidasy MeSH
- dipeptidylpeptidasa 4 MeSH
- hypoglykemika MeSH
- inhibitory dipeptidylpeptidasy 4 MeSH
- inhibitory glykosidových hydrolas MeSH
- krevní glukóza MeSH
- rostlinné extrakty MeSH
The diet rich in fruits and vegetables reduces the risk of metabolic syndrome, including diabetes development by various mechanisms of action, mainly due to the presence of polyphenolic compounds. Extracts from different conifer species are known to be a rich source of various polyphenols. In the present study we elucidated the in vitro mechanism of anti-diabetic activity of silver fir (Abies alba) wood and bark extracts and compared their activity to non-coniferous sweet chestnut wood extract and standardized maritime pine bark extract. Extracts and lignans were tested for their inhibitory activity of enzymes involved in the regulation of blood glucose in vitro. The ability of extracts to protect against oxidative stress in high glucose environment was tested on mouse myoblast cell line. Silver fir wood and bark extracts were shown to be effective inhibitors of α-glucosidase, α-amylase and dipeptidyl peptidase 4, three enzymes involved in the regulation of blood glucose levels. Coniferous extracts also showed protection against oxidative stress generated in high glucose environment. Lignans, particularly pinoresinol diglucoside, isolariciresinol and secolariciresinol were shown to be important contributors of antihyperglycemic activity through inhibition of dipeptidyl peptidase 4. This corroborates previously published in vivo results on blood glucose level obtained with silver fir wood extract and supports the use of silver fir wood and bark extracts as food supplements or functional foods in borderline diabetes.
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