Silver Fir (Abies alba) Extracts Inhibit Enzymes Involved in Blood Glucose Management and Protect against Oxidative Stress in High Glucose Environment
Language English Country Netherlands Media print
Document type Journal Article
Grant support
P4-0127
Javna Agencija za Raziskovalno Dejavnost RS
PubMed
30361961
DOI
10.1007/s11130-018-0698-6
PII: 10.1007/s11130-018-0698-6
Knihovny.cz E-resources
- Keywords
- Diabetes, Digestive enzymes, Lignans, Oxidative stress, Silver fir,
- MeSH
- alpha-Amylases antagonists & inhibitors MeSH
- alpha-Glucosidases metabolism MeSH
- Cell Line MeSH
- Dipeptidyl Peptidase 4 metabolism MeSH
- Wood chemistry MeSH
- Hypoglycemic Agents isolation & purification pharmacology MeSH
- Dipeptidyl-Peptidase IV Inhibitors isolation & purification pharmacology MeSH
- Glycoside Hydrolase Inhibitors isolation & purification pharmacology MeSH
- Abies chemistry MeSH
- Blood Glucose drug effects MeSH
- Plant Bark chemistry MeSH
- Humans MeSH
- Mice MeSH
- Oxidative Stress drug effects MeSH
- Plant Extracts isolation & purification pharmacology MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Mice MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- alpha-Amylases MeSH
- alpha-Glucosidases MeSH
- Dipeptidyl Peptidase 4 MeSH
- Hypoglycemic Agents MeSH
- Dipeptidyl-Peptidase IV Inhibitors MeSH
- Glycoside Hydrolase Inhibitors MeSH
- Blood Glucose MeSH
- Plant Extracts MeSH
The diet rich in fruits and vegetables reduces the risk of metabolic syndrome, including diabetes development by various mechanisms of action, mainly due to the presence of polyphenolic compounds. Extracts from different conifer species are known to be a rich source of various polyphenols. In the present study we elucidated the in vitro mechanism of anti-diabetic activity of silver fir (Abies alba) wood and bark extracts and compared their activity to non-coniferous sweet chestnut wood extract and standardized maritime pine bark extract. Extracts and lignans were tested for their inhibitory activity of enzymes involved in the regulation of blood glucose in vitro. The ability of extracts to protect against oxidative stress in high glucose environment was tested on mouse myoblast cell line. Silver fir wood and bark extracts were shown to be effective inhibitors of α-glucosidase, α-amylase and dipeptidyl peptidase 4, three enzymes involved in the regulation of blood glucose levels. Coniferous extracts also showed protection against oxidative stress generated in high glucose environment. Lignans, particularly pinoresinol diglucoside, isolariciresinol and secolariciresinol were shown to be important contributors of antihyperglycemic activity through inhibition of dipeptidyl peptidase 4. This corroborates previously published in vivo results on blood glucose level obtained with silver fir wood extract and supports the use of silver fir wood and bark extracts as food supplements or functional foods in borderline diabetes.
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