Chimerism as an important marker in post-transplant monitoring chimerism monitoring
Language English Country Great Britain, England Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
30362266
DOI
10.1111/tan.13407
Knihovny.cz E-resources
- Keywords
- chimerism, hematopoietic stem cell transplantation, real-time polymerase chain reaction, short tandem repeats,
- MeSH
- Survival Analysis MeSH
- Adult MeSH
- Genetic Testing methods MeSH
- Hematologic Neoplasms genetics immunology mortality therapy MeSH
- Transplantation, Homologous MeSH
- Immune Tolerance * MeSH
- Cohort Studies MeSH
- Real-Time Polymerase Chain Reaction MeSH
- Middle Aged MeSH
- Humans MeSH
- Adolescent MeSH
- Myeloablative Agonists therapeutic use MeSH
- Graft vs Host Disease diagnosis genetics immunology mortality MeSH
- Graft Survival * MeSH
- Transplantation Conditioning methods MeSH
- Recurrence MeSH
- Graft Rejection diagnosis genetics immunology mortality MeSH
- Risk Factors MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Tandem Repeat Sequences MeSH
- Histocompatibility Testing MeSH
- Hematopoietic Stem Cell Transplantation * MeSH
- Transplantation Chimera genetics immunology MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Adolescent MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Myeloablative Agonists MeSH
Cell chimerism determination is important for the monitoring of engraftment dynamics and for relapse prediction. Our cohort of 474 patients was divided into two groups according to the determination methods used over time, and by their chimerism status. A significant difference in survival was observed between mixed vs complete chimerism (P < 0.0001 vs P < 0.0002) in both patient groups, and also vs microchimerism (P = 0.0201) in the second group. Detection of mixed chimerism is thus a high-risk factor, and microchimerism is potentially a risk factor in the post-transplantation course. Methods with a high sensitivity for monitoring cell chimerism significantly improve the assessment of patients post-transplant, and they enable the identification of patients with high relapse risk. Supported by MH CZ-DRO (00023736, UHKT).
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