Metabolomics Based on MS in Mice with Diet-Induced Obesity and Type 2 Diabetes Mellitus: the Effect of Vildagliptin, Metformin, and Their Combination
Language English Country United States Media print-electronic
Document type Journal Article
PubMed
30393821
DOI
10.1007/s12010-018-2899-8
PII: 10.1007/s12010-018-2899-8
Knihovny.cz E-resources
- Keywords
- Diet-induced obese mice, Mass spectrometry, Metabolomics, Metformin, Plasma, Vildagliptin,
- MeSH
- Diabetes Mellitus, Type 2 blood complications drug therapy metabolism MeSH
- Mass Spectrometry MeSH
- Hypoglycemic Agents administration & dosage therapeutic use MeSH
- Drug Therapy, Combination MeSH
- Metabolomics * MeSH
- Metformin administration & dosage therapeutic use MeSH
- Disease Models, Animal MeSH
- Mice, Inbred C57BL MeSH
- Mice MeSH
- Obesity blood complications metabolism MeSH
- Reproducibility of Results MeSH
- Vildagliptin administration & dosage therapeutic use MeSH
- Animals MeSH
- Check Tag
- Male MeSH
- Mice MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Hypoglycemic Agents MeSH
- Metformin MeSH
- Vildagliptin MeSH
Type 2 diabetes mellitus (T2DM) is a major epidemiological problem. Metformin and vildagliptin are well-established antidiabetic drugs. The aim of the study was to evaluate the changes of plasma metabolic profile induced by a high-fat diet (HFD) and subsequent oral administration of metformin, vildagliptin, and their combination in a mouse model of diet-induced obesity (DIO)/T2DM analyzed using quadrupole-time-of-flight mass spectrometry (qTOF-MS). Metformin treatment increased the levels of butyrylcarnitine and acylcarnitine C18:1 concentrations and decreased the levels of isoleucine concentrations compared to untreated HFD mice. Vildagliptin treatment increased levels of butyrylcarnitine and acetylcarnitine. In summary, our metabolomics study revealed multiple differences between obese diabetic HFD mice and lean standard chow diet (SCD) mice, which were partially modifiable by subsequent metformin and vildagliptin treatment.
Faculty of Applied Sciences University of West Bohemia Univerzitní 8 306 14 Pilsen Czech Republic
Institute of Microbiology The Czech Academy of Sciences Vídeňská 1083 142 20 Prague 4 Czech Republic
Institute of Physiology The Czech Academy of Sciences Vídeňská 1083 142 20 Prague 4 Czech Republic
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