Recent developments and applications of capillary and microchip electrophoresis in proteomics and peptidomics (2015-mid 2018)
Language English Country Germany Media print-electronic
Document type Journal Article, Review
Grant support
17-10832S
Czech Science Foundation
18-02597S
Czech Science Foundation
RVO 61388963
Czech Academy of Sciences
- Keywords
- capillary electrophoresis, mass spectrometry, microchip electrophoresis, peptidomics, proteomics,
- MeSH
- Electrophoresis, Capillary MeSH
- Humans MeSH
- Peptidomimetics analysis MeSH
- Peptides analysis MeSH
- Proteins analysis MeSH
- Proteomics * MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Review MeSH
- Names of Substances
- Peptidomimetics MeSH
- Peptides MeSH
- Proteins MeSH
This review summarizes recent developments and applications of capillary and microchip electroseparation methods in proteomic and peptidomic analyses since the year 2015 to ca. mid 2018. Sample preparation procedures for the removal of interfering components or for pre-fractionation and preconcentration of proteins and peptides of interest are discussed. The innovations in coupling of capillary or microchip electroseparation methods with different modes of mass spectrometry detection are covered. In addition, significant recent applications of capillary electromigration methods in both bottom-up and top-down proteomics as well as in determinations of post-translational modifications of proteins are presented. Moreover, several examples of the utilization of capillary electromigration methods coupled with mass spectrometry detection for clinical proteomics and peptidomics are described.
References provided by Crossref.org
Peptidomics and Capillary Electrophoresis
Microfluidics for Peptidomics, Proteomics, and Cell Analysis
