Although Babesia represents an important worldwide veterinary threat and an emerging risk to humans, this parasite has been poorly studied as compared to Plasmodium, its malaria-causing relative. In fact, Babesia employs highly specific survival strategies during its intraerythrocytic development and its intricate journey through the tick vector. This review introduces a substantially extended molecular phylogeny of the order Piroplasmida, challenging previous taxonomic classifications. The intriguing developmental proficiencies of Babesia are highlighted and compared with those of other haemoparasitic Apicomplexa. Molecular mechanisms associated with distinctive events in the Babesia life cycle are emphasized as potential targets for the development of Babesia-specific treatments.

Institute of Parasitology Biology Centre of the Czech Academy of Sciences CZ 370 05 Ceske Budejovice Czech Republic

Institute of Parasitology Biology Centre of the Czech Academy of Sciences CZ 370 05 Ceske Budejovice Czech Republic; Faculty of Science University of South Bohemia CZ 370 05 Ceske Budejovice Czech Republic

Instituto de Patobiología Veterinaria Centro de Investigaciones en Ciencias Veterinarias y Agronómicas Ciudad Autónoma de Buenos Aires C1033AAJ Argentina

References provided by Crossref.org

Evaluating Antimalarial Proteasome Inhibitors for Efficacy in Babesia Blood Stage Cultures

Establishment of a stable transfection and gene targeting system in Babesia divergens

Role of invasive carnivores (Procyon lotor and Nyctereutes procyonoides) in epidemiology of vector-borne pathogens: molecular survey from the Czech Republic

Babesia, Theileria, Plasmodium and Hemoglobin

Plasmepsin-like Aspartyl Proteases in Babesia

Babesia pisicii n. sp. and Babesia canis Infect European Wild Cats, Felis silvestris, in Romania

Circulation of Babesia Species and Their Exposure to Humans through Ixodes Ricinus