We report two KPC-producing Citrobacter freundii isolates from unrelated patients. In one case, blaKPC-2 was harbored on a novel variant of a Tn4401 transposon of an IncN plasmid conjugated together with a coresident IncA plasmid, whereas in the other one, blaKPC-3 was on a Tn4401a transposon located on an IncX3-IncA self-conjugative plasmid fusion. The interplay among plasmids carrying blaKPC and the coresident IncA plasmids offers new information on plasmids coresident within clinically relevant enterobacteria.

Department of Molecular Medicine Sapienza University of Rome Rome Italy

Faculty of Medicine Biomedical Center Charles University Pilsen Czech Republic

Istituto Superiore di Sanità Rome Italy

S Agostino Estense Baggiovara Hospital Modena Italy

Unit of Microbiology and Clinical Microbiology Department of Clinical Surgical Diagnostic and Pediatric Sciences University of Pavia Pavia Italy

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