Unraveling corticobasal syndrome and alien limb syndrome with structural brain imaging
Jazyk angličtina Země Itálie Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
30927559
DOI
10.1016/j.cortex.2019.02.015
PII: S0010-9452(19)30067-X
Knihovny.cz E-zdroje
- Klíčová slova
- Alien limb syndrome, Anarchic limb syndrome, Corticobasal syndrome, Diagnosis prediction, Support vector machine,
- MeSH
- lidé středního věku MeSH
- lidé MeSH
- magnetická rezonanční tomografie MeSH
- mozek diagnostické zobrazování MeSH
- parkinsonské poruchy diagnostické zobrazování MeSH
- počítačové zpracování obrazu MeSH
- senioři MeSH
- syndrom cizí končetiny diagnostické zobrazování MeSH
- Check Tag
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
Alien limb phenomenon is a rare syndrome associated with a feeling of non-belonging and disowning toward one's limb. In contrast, anarchic limb phenomenon leads to involuntary but goal-directed movements. Alien/anarchic limb phenomena are frequent in corticobasal syndrome (CBS), an atypical parkinsonian syndrome characterized by rigidity, akinesia, dystonia, cortical sensory deficit, and apraxia. The structure-function relationship of alien/anarchic limb was investigated in multi-centric structural magnetic resonance imaging (MRI) data. Whole-group and single-subject comparisons were made in 25 CBS and eight CBS-alien/anarchic limb patients versus controls. Support vector machine was used to see if CBS with and without alien/anarchic limb could be distinguished by structural MRI patterns. Whole-group comparison of CBS versus controls revealed asymmetric frontotemporal atrophy. CBS with alien/anarchic limb syndrome versus controls showed frontoparietal atrophy including the supplementary motor area contralateral to the side of the affected limb. Exploratory analysis identified frontotemporal regions encompassing the pre-/and postcentral gyrus as compromised in CBS with alien limb syndrome. Classification of CBS patients yielded accuracies of 79%. CBS-alien/anarchic limb syndrome was differentiated from CBS patients with an accuracy of 81%. Predictive differences were found in the cingulate gyrus spreading to frontomedian cortex, postcentral gyrus, and temporoparietoocipital regions. We present the first MRI-based group analysis on CBS-alien/anarchic limb. Results pave the way for individual clinical syndrome prediction and allow understanding the underlying neurocognitive architecture.
Clinic for Neurology University of Ulm Germany
FTLD Consortium Germany Germany; Clinic for Neurology Saarland University Germany
FTLD Consortium Germany Germany; Clinic for Neurology University of Ulm Germany
FTLD Consortium Germany Germany; Clinic of Neurology Ludwig Maximilian University of Munich Germany
Max Planck Institute for Human Cognitive and Brain Sciences Leipzig Germany
Citace poskytuje Crossref.org
