Oral anticoagulation in patients presenting with non-valvular atrial fibrillation and a CHA2DS2-VASc score of 1 (CHA2DS2-VASc of 2 in women) remains a challenging approach in clinical practice. Therapeutic decisions need to balance the individual benefit of reducing thromboembolic risk against the potential harm due to an increase in bleeding risk in this intermediate risk patient population. Within the current opinion statement of the European Society of Cardiology working group of cardiovascular pharmacotherapy and the European Society of Cardiology council on stroke the currently available evidence on the anti-thrombotic management in patients presenting with a CHA2DS2-VASc of 1 is summarized. Easily applicable tools for a personalized refinement of the individual thromboembolic risk in patients with atrial fibrillation and a CHA2DS2-VASc score of 1 that guide clinicians through the question whether to anticoagulate or not are provided.

Atherosclerosis Research Unit Medical and Surgical Sciences Department Sant'Orsola Malpighi Hospital University of Bologna Via Zamboni 33 40126 Comune di Bologna BO Italy

BIH Center for Regenerative Therapies Charité Universitaetsmedizin Berlin Charitéplatz 1 10117 Berlin Germany

Cardiocenter 3rd Faculty of Medicine Charles University Opletalova 38 110 00 Staré Město Prague Czech Republic

Cardiology Division Department of Medicine Karolinska Institute Karolinska University Hospital Eugeniavägen 3 171 76 Solna Stockholm Sweden

Cardiology Pasing Institutstraße 14 81241 Munich Germany

Department of Cardiology Aalborg University Hospital Fredrik Bajers Vej 5 9100 Aalborg Denmark

Department of Cardiology Copenhagen University Hospital Blegdamsvej 9 2100 Copenhagen Denmark

Department of Cardiology Oslo University Hospital and Institute of Clinical Medicine Oslo University Klaus Torgírds vei 3 0372 Oslo Norway

Department of Cardiology Oudenarder Straße 16 13316 Berlin Germany

Department of Health Science and Technology The Faculty of Medicine Aalborg University Fredrik Bajers Vej 5 9100 Aalborg Denmark

Department of Health Sciences and Technology Aalborg University Fredrik Bajers Vej 5 9100 Aalborg Denmark

Department of Internal Medicine Cardiology and Nephrology Landesklinikum Wiener Neustadt Corvinusring 3 5 2700 Wiener Neustadt Austria

Department of Pharmacology and Toxicology School of Medicine Universidad Complutense Avda de Séneca 2 Ciudad Universitaria 28040 Madrid Spain

Department of Rheumatology Preventive Cardio Rheuma Clinic Diakonhjemmet Hospital Diakonveien 12 0370 Oslo Norway

Division of Cardiology Department of Internal Medicine 2 Medical University of Vienna Waehringer Guertel 18 20 1090 Vienna Austria

Emergency Department Bispebjerg and Frederiksberg Hospital University of Copenhagen Bispebjerg Bakke 23 2400 Copenhagen Denmark

IRCCS San Raffaele Roma Via della Pisana 235 00163 Roma Italy

Lady Davis Carmel Medical Center Mikhal St 7 3436212 Haifa Israel

Molecular and Clinical Sciences Research Institute St George's University of London Cranmer Terrace Tooting London SW17 0RE UK

Private University of the Principality of Liechtenstein Dorfstrasse 24 FL 9495 Triesen Principality of Liechtenstein

St George's Hospitals NHS Trust University of London Cranmer Terrace Tooting London SW17 0RE UK

Technion Israel Institute of Technology Ruth and Bruce Rappaport School of Medicine Efron St 1 3436212 Haifa Israel

University of the Saarland Kirrberger Straße 100 66424 Homburg Saar Germany

VIVIT Research Landeskrankenhaus Feldkirch Carinagasse 47 6800 Feldkirch Austria

Eur Heart J Cardiovasc Pharmacother. 2020 Jul 1;6(4):265-266. doi: 10.1093/ehjcvp/pvz039. PubMed

Eur Heart J Cardiovasc Pharmacother. 2020 Jul 1;6(4):267-268. doi: 10.1093/ehjcvp/pvz040. PubMed

Eur Heart J Cardiovasc Pharmacother. 2020 Jul 1;6(4):252. doi: 10.1093/ehjcvp/pvaa035. PubMed

Eur Heart J Cardiovasc Pharmacother. 2020 Sep 1;6(5):309. doi: 10.1093/ehjcvp/pvaa081. PubMed

Citace poskytuje Crossref.org

Cardiovascular care of patients with stroke and high risk of stroke: The need for interdisciplinary action: A consensus report from the European Society of Cardiology Cardiovascular Round Table