Dynamic of mitochondrial network, cristae, and mitochondrial nucleoids in pancreatic β-cells
Language English Country Netherlands Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't, Review
PubMed
31252091
DOI
10.1016/j.mito.2019.06.007
PII: S1567-7249(19)30022-4
Knihovny.cz E-resources
- Keywords
- Mitochondrial cristae, Mitochondrial network, Mitochondrial nucleoids, Type 2 diabetes,
- MeSH
- Insulin-Secreting Cells metabolism ultrastructure MeSH
- Diabetes Mellitus, Type 2 metabolism pathology MeSH
- Humans MeSH
- Mitochondrial Dynamics * MeSH
- Mitochondrial Membranes metabolism ultrastructure MeSH
- Mitochondria metabolism ultrastructure MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
Type 2 diabetes progression stems from dysfunction of β-cells, besides the peripheral insulin resistance. Mitochondria as glucose sensor and regulation center are impaired at various stages of this progression. Their biogenesis and functional impairment is reflected by altered morphology of the mitochondrial network and ultramorphology of cristae and mitochondrial DNA loci, termed nucleoids. Aspects of all above changes are reviewed here together with a brief introduction to proteins involved in mitochondrial network dynamics, cristae shaping, and mtDNA nucleoid structure and maintenance. Most frequently, pathology is reflected by the fragmentation of network, cristae inflation or absence and declining number of nucleoids.
References provided by Crossref.org
Possible frequent multiple mitochondrial DNA copies in a single nucleoid in HeLa cells
