Anthelmintics in the future: current trends in the discovery and development of new drugs against gastrointestinal nematodes
Language English Country England, Great Britain Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't, Review
PubMed
31883953
DOI
10.1016/j.drudis.2019.12.007
PII: S1359-6446(19)30466-0
Knihovny.cz E-resources
- MeSH
- Anthelmintics chemistry therapeutic use MeSH
- Biological Products therapeutic use MeSH
- Drug Combinations MeSH
- Gastrointestinal Diseases drug therapy veterinary MeSH
- Humans MeSH
- Nematode Infections drug therapy veterinary MeSH
- Drug Discovery MeSH
- Drug Repositioning MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
- Names of Substances
- Anthelmintics MeSH
- Biological Products MeSH
- Drug Combinations MeSH
The control of gastrointestinal nematodes (GINs), the most abundant and serious parasites of livestock, has become difficult because of the limited number of available drugs and fast development of drug resistance. Thus, considerable efforts have been devoted to developing new anthelmintics that are efficient against nematodes, especially resistant species. Here, we summarize the most recent results using various approaches: target-based or high-throughput screening (HTS) of compound libraries; the synthesis of new derivatives or new combinations of current anthelmintics; the repurposing of drugs currently approved for other indications; and lastly, the identification of active plant products. We also evaluate the advantages and disadvantages of each of these approaches.
References provided by Crossref.org
Anthelmintic activity of European fern extracts against Haemonchus contortus
