Alternative Mechanisms of p53 Action During the Unfolded Protein Response
Status PubMed-not-MEDLINE Jazyk angličtina Země Švýcarsko Médium electronic
Typ dokumentu časopisecké články, přehledy
Grantová podpora
MEYS - NPS I - LO1413
Ministerstvo Školství, Mládeže a Tělovýchovy
MH CZ - DRO (MMCI, 00209805)
Ministerstvo Zdravotnictví Ceské Republiky
180296
Cancerfonden
PubMed
32050651
PubMed Central
PMC7072472
DOI
10.3390/cancers12020401
PII: cancers12020401
Knihovny.cz E-zdroje
- Klíčová slova
- ER stress, UPR, mRNA translation, p47, p53,
- Publikační typ
- časopisecké články MeSH
- přehledy MeSH
The tumor suppressor protein p53 orchestrates cellular responses to a vast number of stresses, with DNA damage and oncogenic activation being some of the best described. The capacity of p53 to control cellular events such as cell cycle progression, DNA repair, and apoptosis, to mention some, has been mostly linked to its role as a transcription factor. However, how p53 integrates different signaling cascades to promote a particular pathway remains an open question. One way to broaden its capacity to respond to different stimuli is by the expression of isoforms that can modulate the activities of the full-length protein. One of these isoforms is p47 (p53/47, Δ40p53, p53ΔN40), an alternative translation initiation variant whose expression is specifically induced by the PERK kinase during the Unfolded Protein Response (UPR) following Endoplasmic Reticulum stress. Despite the increasing knowledge on the p53 pathway, its activity when the translation machinery is globally suppressed during the UPR remains poorly understood. Here, we focus on the expression of p47 and we propose that the alternative initiation of p53 mRNA translation offers a unique condition-dependent mechanism to differentiate p53 activity to control cell homeostasis during the UPR. We also discuss how the manipulation of these processes may influence cancer cell physiology in light of therapeutic approaches.
Department of Medical Biosciences Umeå University 90185 Umeå Sweden
ICCVS University of Gdańsk Science ul Wita Stwosza 63 80 308 Gdańsk Poland
INSERM U1162 27 rue Juliette Dodu 75010 Paris France
RECAMO Masaryk Memorial Cancer Institute Zluty kopec 7 656 53 Brno Czech Republic
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