Short but Weak: The Z-DNA Lone-Pair⋅⋅⋅π Conundrum Challenges Standard Carbon Van der Waals Radii
Jazyk angličtina Země Německo Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
32516461
DOI
10.1002/anie.202004201
Knihovny.cz E-zdroje
- Klíčová slova
- Z-DNA, lp⋅⋅⋅π interactions, molecular recognition, non-covalent interactions, van der Waals radii,
- MeSH
- hydrofobní a hydrofilní interakce MeSH
- kvantová teorie * MeSH
- uhlík chemie MeSH
- Z-DNA chemie MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- uhlík MeSH
- Z-DNA MeSH
Current interest in lone-pair⋅⋅⋅π (lp⋅⋅⋅π) interactions is gaining momentum in biochemistry and (supramolecular) chemistry. However, the physicochemical origin of the exceptionally short (ca. 2.8 Å) oxygen-to-nucleobase plane distances observed in prototypical Z-DNA CpG steps remains unclear. High-level quantum mechanical calculations, including SAPT2+3 interaction energy decompositions, demonstrate that lp⋅⋅⋅π contacts do not result from n→π* orbital overlaps but from weak dispersion and electrostatic interactions combined with stereochemical effects imposed by the locally strained structural context. They also suggest that the carbon van der Waals (vdW) radii, originally derived for sp3 carbons, should not be used for smaller sp2 carbons attached to electron-withdrawing groups. Using a more adapted carbon vdW radius results in these lp⋅⋅⋅π contacts being no longer of the sub-vdW type. These findings challenge the whole lp⋅⋅⋅π concept that refers to elusive orbital interactions that fail to explain short interatomic contact distances.
Institute of Biophysics of the Czech Academy of Sciences Královopolská 135 61265 Brno Czech Republic
Université de Strasbourg CNRS Architecture et Réactivité de l'ARN UPR9002 F 67000 Strasbourg France
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