Octahedral Molybdenum Cluster Complexes with Optimized Properties for Photodynamic Applications
Language English Country United States Media print-electronic
Document type Journal Article
- MeSH
- Apoptosis drug effects MeSH
- Photosensitizing Agents chemical synthesis pharmacology radiation effects MeSH
- HeLa Cells MeSH
- Coordination Complexes chemical synthesis pharmacology radiation effects MeSH
- Humans MeSH
- Ligands MeSH
- Lysosomes metabolism MeSH
- Molybdenum chemistry radiation effects MeSH
- Antineoplastic Agents chemical synthesis pharmacology radiation effects MeSH
- Drug Screening Assays, Antitumor MeSH
- Singlet Oxygen metabolism MeSH
- Light MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Photosensitizing Agents MeSH
- Coordination Complexes MeSH
- Ligands MeSH
- Molybdenum MeSH
- Antineoplastic Agents MeSH
- Singlet Oxygen MeSH
Two new octahedral molybdenum cluster complexes act as an efficient singlet oxygen supplier in the context of the photodynamic therapy of cancer cells under blue-light irradiation. These complexes integrate the {Mo6I8}4+ core with 4'-carboxybenzo-15-crown-5 or cholate apical ligands and were characterized by 1H NMR, HR ESI-MS, and CHN elemental analysis. Both complexes display high quantum yields of luminescence and singlet oxygen formation in aqueous media associated with a suitable stability against hydrolysis. They are internalized into lysosomes of HeLa cells with no dark toxicity at pharmacologically relevant concentrations and have a strong phototoxic effect under blue-light irradiation, even in the presence of fetal bovine serum. The last feature is essential for further translation to in vivo experiments. Overall, these complexes are attractive molecular photosensitizers toward photodynamic applications.
References provided by Crossref.org
Octahedral Molybdenum Cluster-Based Nanomaterials for Potential Photodynamic Therapy
