Wnt signaling plays an important role in the self-renewal, fate-commitment and survival of the neural stem/progenitor cells (NS/PCs) of the adult central nervous system (CNS). Ischemic stroke impairs the proper functioning of the CNS and, therefore, active Wnt signaling may prevent, ameliorate, or even reverse the negative effects of ischemic brain injury. In this review, we provide the current knowledge of Wnt signaling in the adult CNS, its status in diverse cell types, and the Wnt pathway's impact on the properties of NS/PCs and glial cells in the context of ischemic injury. Finally, we summarize promising strategies that might be considered for stroke therapy, and we outline possible future directions of the field.

2nd Faculty of Medicine Charles University 84 5 Uvalu 150 06 Prague Czech Republic

Institute of Experimental Medicine Czech Academy of Sciences 1083 Videnska 142 20 Prague Czech Republic

Institute of Molecular Genetics Czech Academy of Sciences 1083 Videnska 142 20 Prague Czech Republic

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On the Common Journey of Neural Cells through Ischemic Brain Injury and Alzheimer's Disease

Wnt/β-Catenin Signaling Promotes Differentiation of Ischemia-Activated Adult Neural Stem/Progenitor Cells to Neuronal Precursors