Anti-inflammatory and antioxidant properties of chemical constituents of Broussonetia papyrifera
Language English Country United States Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
33011537
DOI
10.1016/j.bioorg.2020.104298
PII: S0045-2068(20)31596-0
Knihovny.cz E-resources
- Keywords
- Anti-inflammatory, Antioxidant, Broussonetia papyrifera, NF-κB,
- MeSH
- Anti-Inflammatory Agents chemistry isolation & purification pharmacology MeSH
- Antioxidants chemistry isolation & purification pharmacology MeSH
- Broussonetia chemistry MeSH
- Interleukin-1beta antagonists & inhibitors biosynthesis MeSH
- Cells, Cultured MeSH
- Humans MeSH
- Lipopolysaccharides antagonists & inhibitors pharmacology MeSH
- Molecular Structure MeSH
- NF-kappa B analysis antagonists & inhibitors biosynthesis MeSH
- Oxidative Stress drug effects MeSH
- THP-1 Cells MeSH
- Tumor Necrosis Factor-alpha antagonists & inhibitors biosynthesis MeSH
- Transcription Factor AP-1 analysis antagonists & inhibitors biosynthesis MeSH
- Cell Survival drug effects MeSH
- Dose-Response Relationship, Drug MeSH
- Structure-Activity Relationship MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Anti-Inflammatory Agents MeSH
- Antioxidants MeSH
- IL1B protein, human MeSH Browser
- Interleukin-1beta MeSH
- Lipopolysaccharides MeSH
- NF-kappa B MeSH
- Tumor Necrosis Factor-alpha MeSH
- Transcription Factor AP-1 MeSH
Extensive phytochemical analysis of the CHCl3-soluble part of an ethanolic extract of branches and twigs of Broussonetia papyrifera led to the isolation of fourteen compounds, including a novel 5,11-dioxabenzo[b]fluoren-10-one derivative named broussofluorenone C (12). The isolated compounds 1-14 were characterized based on their NMR and HRMS data, and examined for their anti-inflammatory activities in LPS-stimulated THP-1 cells as well as for their cellular antioxidant effects. Compounds 7-10 and 12 showed inhibitory effects on NF-κB/AP-1 activation and compounds 7-9 were subsequently confirmed to suppress the secretion of both IL-1β and TNF-α in LPS-stimulated THP-1 cells more significantly than the prednisone used as a positive control. In the CAA assay, compound 10 exhibited the greatest antioxidant effect, greater than that of the quercetin used as a positive control. The results show possible beneficial effects and utilization of B. papyrifera wood in the treatment of inflammatory diseases as well as oxidative stress.
References provided by Crossref.org
Dibenzocyclooctadiene Lignans from Schisandra chinensis with Anti-Inflammatory Effects
Antioxidant and Anti-Inflammatory Activity of Five Medicinal Mushrooms of the Genus Pleurotus
Direct and Indirect Antioxidant Effects of Selected Plant Phenolics in Cell-Based Assays
