Anti-inflammatory and antioxidant properties of chemical constituents of Broussonetia papyrifera
Jazyk angličtina Země Spojené státy americké Médium print-electronic
Typ dokumentu časopisecké články, práce podpořená grantem
PubMed
33011537
DOI
10.1016/j.bioorg.2020.104298
PII: S0045-2068(20)31596-0
Knihovny.cz E-zdroje
- Klíčová slova
- Anti-inflammatory, Antioxidant, Broussonetia papyrifera, NF-κB,
- MeSH
- antiflogistika chemie izolace a purifikace farmakologie MeSH
- antioxidancia chemie izolace a purifikace farmakologie MeSH
- Broussonetia chemie MeSH
- interleukin-1beta antagonisté a inhibitory biosyntéza MeSH
- kultivované buňky MeSH
- lidé MeSH
- lipopolysacharidy antagonisté a inhibitory farmakologie MeSH
- molekulární struktura MeSH
- NF-kappa B analýza antagonisté a inhibitory biosyntéza MeSH
- oxidační stres účinky léků MeSH
- THP-1 buňky MeSH
- TNF-alfa antagonisté a inhibitory biosyntéza MeSH
- transkripční faktor AP-1 analýza antagonisté a inhibitory biosyntéza MeSH
- viabilita buněk účinky léků MeSH
- vztah mezi dávkou a účinkem léčiva MeSH
- vztahy mezi strukturou a aktivitou MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- antiflogistika MeSH
- antioxidancia MeSH
- IL1B protein, human MeSH Prohlížeč
- interleukin-1beta MeSH
- lipopolysacharidy MeSH
- NF-kappa B MeSH
- TNF-alfa MeSH
- transkripční faktor AP-1 MeSH
Extensive phytochemical analysis of the CHCl3-soluble part of an ethanolic extract of branches and twigs of Broussonetia papyrifera led to the isolation of fourteen compounds, including a novel 5,11-dioxabenzo[b]fluoren-10-one derivative named broussofluorenone C (12). The isolated compounds 1-14 were characterized based on their NMR and HRMS data, and examined for their anti-inflammatory activities in LPS-stimulated THP-1 cells as well as for their cellular antioxidant effects. Compounds 7-10 and 12 showed inhibitory effects on NF-κB/AP-1 activation and compounds 7-9 were subsequently confirmed to suppress the secretion of both IL-1β and TNF-α in LPS-stimulated THP-1 cells more significantly than the prednisone used as a positive control. In the CAA assay, compound 10 exhibited the greatest antioxidant effect, greater than that of the quercetin used as a positive control. The results show possible beneficial effects and utilization of B. papyrifera wood in the treatment of inflammatory diseases as well as oxidative stress.
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