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A review on advances in graphene-derivative/polysaccharide bionanocomposites: Therapeutics, pharmacogenomics and toxicity

Makvandi, Pooyan
Author Makvandi, Pooyan Istituto Italiano di Tecnologia, Centre for Micro-BioRobotics, viale Rinaldo Piaggio 34, Pontedera, Pisa, 56025, Italy; Department of Medical Nanotechnology, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran, 14496-14535, Iran. Electronic address: pooyanmakvandi@gmail.com
Ghomi, Matineh
Author Ghomi, Matineh Chemistry Department, Faculty of Science, Shahid Chamran University of Ahvaz, Ahvaz, 6153753843, Iran
Ashrafizadeh, Milad
Author Ashrafizadeh, Milad Department of Basic Science, Faculty of Veterinary Medicine, University of Tabriz, Tabriz, 51666-16471, Iran
Tafazoli, Alireza
Author Tafazoli, Alireza Department of Analysis and Bioanalysis of Medicines, Faculty of Pharmacy with the Division of Laboratory Medicine, Medical University of Białystok, Białystok, 15-089, Poland
Agarwal, Tarun
Author Agarwal, Tarun Department of Biotechnology, Indian Institute of Technology, Kharagpur, 721302, India
Delfi, Masoud
Author Delfi, Masoud Department of Chemical Sciences, University of Naples "Federico II", Naples, 80126, Italy
Akhtari, Javad
Author Akhtari, Javad Toxoplasmosis Research Center, Communicable Diseases Institute, Department of Medical Nanotechnology, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
Zare, Ehsan Nazarzade
Author Zare, Ehsan Nazarzade School of Chemistry, Damghan University, Damghan, 36716-41167, Iran
Padil, Vinod V T
Author Padil, Vinod V T Department of Nanomaterials in Natural Sciences, Institute for Nanomaterials, Advanced Technologies and Innovation (CXI), Technical University of Liberec (TUL), Studentská, 1402/2, Liberec, Czech Republic
Zarrabi, Ali
Author Zarrabi, Ali Sabanci University Nanotechnology Research and Application Center (SUNUM), Tuzla, Istanbul, 34956, Turkey; Center of Excellence for Functional Surfaces and Interfaces (EFSUN), Faculty of Engineering and Natural Sciences, Sabanci University, Tuzla, Istanbul, 34956, Turkey
Pourreza, Nahid
Author Pourreza, Nahid Chemistry Department, Faculty of Science, Shahid Chamran University of Ahvaz, Ahvaz, 6153753843, Iran
Miltyk, Wojciech
Author Miltyk, Wojciech Department of Analysis and Bioanalysis of Medicines, Faculty of Pharmacy with the Division of Laboratory Medicine, Medical University of Białystok, Białystok, 15-089, Poland
Maiti, Tapas Kumar
Author Maiti, Tapas Kumar Department of Biotechnology, Indian Institute of Technology, Kharagpur, 721302, India

Carbohydrate polymers. 2020 Dec 15 ; 250 () : 116952. [epub] 20200822

Carbohydr Polym
ISSN 1879-1344 | 0144-8617
Source

Language English Country Great Britain, England Media print-electronic

Document type Journal Article, Review

Persistent link https://www.medvik.cz/link/pmid33049857

PubMed 33049857
DOI 10.1016/j.carbpol.2020.116952
PII: S0144-8617(20)31125-5
Knihovny.cz E-resources

Keywords
Antimicrobial therapy, Co-delivery, Drug delivery, Graphene oxide nanocomposites, Polysaccharide Bionanocomposites,
MeSH
Antineoplastic Agents chemistry pharmacology MeSH
Pharmacogenetics * MeSH
Graphite chemistry MeSH
Humans MeSH
Neoplasms drug therapy genetics pathology MeSH
Nanocomposites administration & dosage chemistry MeSH
Drug-Related Side Effects and Adverse Reactions etiology pathology MeSH
Polysaccharides chemistry pharmacology MeSH
Check Tag
Humans MeSH
Publication type
Journal Article MeSH
Review MeSH
Names of Substances
Antineoplastic Agents MeSH
Graphite MeSH
Polysaccharides MeSH

Graphene-based bionanocomposites are employed in several ailments, such as cancers and infectious diseases, due to their large surface area (to carry drugs), photothermal properties, and ease of their functionalization (owing to their active groups). Modification of graphene-derivatives with polysaccharides is a promising strategy to decrease their toxicity and improve target ability, which consequently enhances their biotherapeutic efficacy. Herein, functionalization of graphene-based materials with carbohydrate polymers (e.g., chitosan, starch, alginate, hyaluronic acid, and cellulose) are presented. Subsequently, recent advances in graphene nanomaterial/polysaccharide-based bionanocomposites in infection treatment and cancer therapy are comprehensively discussed. Pharmacogenomic and toxicity assessments for these bionanocomposites are also highlighted to provide insight for future optimized and smart investigations and researches.

Chemistry Department Faculty of Science Shahid Chamran University of Ahvaz Ahvaz 6153753843 Iran

Department of Analysis and Bioanalysis of Medicines Faculty of Pharmacy with the Division of Laboratory Medicine Medical University of Białystok Białystok 15 089 Poland

Department of Basic Science Faculty of Veterinary Medicine University of Tabriz Tabriz 51666 16471 Iran

Department of Biotechnology Indian Institute of Technology Kharagpur 721302 India

Department of Chemical Sciences University of Naples Federico 2 Naples 80126 Italy

Department of Nanomaterials in Natural Sciences Institute for Nanomaterials Advanced Technologies and Innovation Studentská 1402 2 Liberec Czech Republic

Istituto Italiano di Tecnologia Centre for Micro BioRobotics viale Rinaldo Piaggio 34 Pontedera Pisa 56025 Italy; Department of Medical Nanotechnology Faculty of Advanced Technologies in Medicine Iran University of Medical Sciences Tehran 14496 14535 Iran

Sabanci University Nanotechnology Research and Application Center Faculty of Engineering and Natural Sciences Sabanci University Tuzla Istanbul 34956 Turkey

School of Chemistry Damghan University Damghan 36716 41167 Iran

Toxoplasmosis Research Center Communicable Diseases Institute Department of Medical Nanotechnology Faculty of Medicine Mazandaran University of Medical Sciences Sari Iran

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