This review is focused on the study of the effects of grape seed and skin extract (GSSE) on human health. GSSE contains high concentrations of important polyphenolic substances with high biological activity. This review is a summary of studies that investigate the effects of GSSE on diabetes mellitus, cardiovascular disease and cancer, its neuroprotective effect, and its effects on the gastrointestinal tract and other health complications related to these diseases. The results of the studies confirm that the anti-inflammatory, antiapoptotic, and pro-proliferative effects of "Vitis vinifera L." seed extract reduce the level of oxidative stress and improve the overall lipid metabolism.

Centre of Experimental Medicine Slovak Academy of Sciences Institute of Normal and Pathological Physiology 841 04 Bratislava Slovakia

Department of Food Analysis and Chemistry Faculty of Technology Tomas Bata University in Zlin Vavrečkova 275 760 01 Zlin Czech Republic

Department of Food Technology Faculty of Agronomy Mendel University in Brno Zemedelska 1 613 00 Brno Czech Republic

Department of Viticulture and Enology Faculty of Horticulture Mendel University in Brno Valtická 337 691 44 Lednice Czech Republic

Faculty of Central European Studies Institute for Teacher Training Constantine the Philosopher University in Nitra Drazovska 4 SK 949 74 Nitra Slovakia

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