- MeSH
- Grape Seed Extract * therapeutic use MeSH
- Phytotherapy MeSH
- Plants, Medicinal MeSH
- Humans MeSH
- Proanthocyanidins therapeutic use MeSH
- Plant Extracts MeSH
- Aging MeSH
- Vitis MeSH
- Check Tag
- Humans MeSH
- Publication type
- Popular Work MeSH
Plant lignans possess several properties beneficial for human health and therefore, increasing their contents in foods and beverages is desirable. One of the lignan sources in human diet is wine. To elucidate the origin of lignans contained in wine, LC-MS was used to analyze resinol-related lignans in must, seeds, stems, and wine prepared using stainless steel tanks, oak barrels, and Qvevri (clay vessel). White wines aged in stainless steel tanks contained significantly lower amounts of lignan aglycones (20-60 µg/L) than red and Qvevri wines (300-500 µg/L). Generally, white wines aged in stainless steel tanks contained only low amounts of isolariciresinol and matairesinol. Qvevri wines and red wine aged in stainless steel tank contained up to five lignan compounds and in wine aged in oak barrel, six different lignans were identified. Consistently, only low concentration of isolariciresinol has been found in must, whereas more lignan compounds have been found in grape seeds (isolariciresinol, secoisolariciresinol, and pinoresinol) and stems (isolariciresinol and syringaresinol). Consequently, we conclude that lignan content in wine can be increased by maturation in contact with grape berries, seeds, or stems or with wood.
Cadmium (Cd) is a heavy metal that occurs in all areas of the environment, including the food chain. In the body, it causes oxidative stress by producing free radicals that are harmful to the cells. Grape seed extract (GSE) contains a wide range of biologically active components that help to neutralize the adverse effects of free radicals. In this study, the effects of GSE prepared form semi-resistant grapevine cultivar Cerason, which is rich in phenolics, on biochemical markers of brown rats exposed to the effects of cadmium were monitored. GSE increased the plasma antioxidant activity and, in the kidneys and the liver, Cd content was significantly lowered by GSE co-administration. Accordingly, the increase in creatinine content and alanine aminotransferase activity and the decrease of catalase and superoxide dismutase activities caused by cadmium were slowed down by GSE co-administration. The results of this work reveal that grape seed extract offers a protective effect against the intake of heavy metals into the organism.
- MeSH
- Alanine Transaminase blood MeSH
- Antioxidants analysis MeSH
- Aspartate Aminotransferases blood MeSH
- Biomarkers metabolism MeSH
- Grape Seed Extract pharmacology MeSH
- Phytochemicals analysis MeSH
- Liver drug effects enzymology metabolism MeSH
- Cadmium blood MeSH
- Catalase metabolism MeSH
- Creatinine blood MeSH
- Kidney drug effects metabolism MeSH
- Metallothionein metabolism MeSH
- Urea blood MeSH
- Rats, Wistar MeSH
- Seeds chemistry MeSH
- Superoxide Dismutase metabolism MeSH
- Health * MeSH
- Animals MeSH
- Check Tag
- Animals MeSH
- Publication type
- Journal Article MeSH
This review is focused on the study of the effects of grape seed and skin extract (GSSE) on human health. GSSE contains high concentrations of important polyphenolic substances with high biological activity. This review is a summary of studies that investigate the effects of GSSE on diabetes mellitus, cardiovascular disease and cancer, its neuroprotective effect, and its effects on the gastrointestinal tract and other health complications related to these diseases. The results of the studies confirm that the anti-inflammatory, antiapoptotic, and pro-proliferative effects of "Vitis vinifera L." seed extract reduce the level of oxidative stress and improve the overall lipid metabolism.
- MeSH
- Biomarkers metabolism MeSH
- Grape Seed Extract pharmacology MeSH
- Humans MeSH
- Lipids blood MeSH
- Disease MeSH
- Neuroprotective Agents pharmacology MeSH
- Health * MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Review MeSH
Vitis vinifera, neboli réva vinná, je ekonomicky významná plodina. Během pěstovaní révy vinné dochází k produkci bioodpadů, které mohou být zdrojem mnoha prospěšných látek. Největší potenciál představuje využití polyfenolových látek obsažených v stoncích, listech, slupkách a semenech hroznů. Biologická aktivita těchto látek spočívá především v jejich antioxidačních, antimikrobiálních a protizánětlivých vlastnostech, které mohou byt využity ve farmaceutickém, potravinářském a kosmetickém průmyslu.
Vitis vinifera, or grapevine, is economically significant crop. However, the winemaking industry is one of the major producers of bio-waste that can be a source of many valuable substances. The greatest potential is represented by polyphenolic substances which are contained in stems, leaves, peels and grape seeds. The biological activity of these substances is based on their antioxidant, antimicrobial and anti- -inflammatory properties, which can be used in the pharmaceutical, food and cosmetic industries.
Characterizations of fatty acids composition in % of total methylester of fatty acids (FAMEs) of fourteen vegetable oils--safflower, grape, silybum marianum, hemp, sunflower, wheat germ, pumpkin seed, sesame, rice bran, almond, rapeseed, peanut, olive, and coconut oil--were obtained by using gas chromatography (GC). Saturated (SFA), monounsaturated (MUFA) and polyunsaturated fatty acids (PUFA), palmitic acid (C16:0; 4.6%-20.0%), oleic acid (C18:1; 6.2%-71.1%) and linoleic acid (C18:2; 1.6%-79%), respectively, were found predominant. The nutritional aspect of analyzed oils was evaluated by determination of the energy contribution of SFAs (19.4%-695.7% E(RDI)), PUFAs (10.6%-786.8% E(RDI)), n-3 FAs (4.4%-117.1% E(RDI)) and n-6 FAs (1.8%-959.2% E(RDI)), expressed in % E(RDI) of 1 g oil to energy recommended dietary intakes (E(RDI)) for total fat (E(RDI)--37.7 kJ/g). The significant relationship between the reported data of total fat, SFAs, MUFAs and PUFAs intakes (% E(RDI)) for adults and mortality caused by coronary heart diseases (CHD) and cardiovascular diseases (CVD) in twelve countries has not been confirmed by Spearman's correlations.
- MeSH
- Energy Intake * MeSH
- Cardiovascular Diseases epidemiology mortality prevention & control MeSH
- Humans MeSH
- Fatty Acids administration & dosage analysis MeSH
- Plant Oils administration & dosage chemistry MeSH
- Nutrition Policy * MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
Effects of active ingredients from topical and systemic skincare products on structure and organization of epidermis, dermal-epidermal junction (DEJ), and dermis were examined using an in vitro reconstructed skin equivalent (SE). Imedeen Time Perfection (ITP) ingredients (a mixture of BioMarine Complex, grape seed extract, tomato extract, vitamin C) were supplemented systemically into culture medium. Kinetin, an active ingredient from Imedeen Expression Line Control Serum, was applied topically. Both treatments were tested separately or combined. In epidermis, all treatments stimulated keratinocyte proliferation, showing a significant increase of Ki67-positive keratinocytes (P < 0.05). Kinetin showed a twofold increase of Ki67-positive cells, ITP resulted in a fivefold, and ITP+kinetin showed a nine-fold increase. Differentiation of keratinocytes was influenced only by kinetin since filaggrin was found only in kinetin and kinetin+ITP samples. At the DEJ, laminin 5 was slightly increased by all treatments. In dermis, only ITP increased the amount of collagen type I. Both kinetin and ITP stimulated formation of fibrillin-1 and elastin deposition. The effect of kinetin was seen in upper dermis. It stimulated not only the amount of deposited fibrillin-1 and elastin fibers but also their organization perpendicularly to the DEJ. ITP stimulated formation of fibrillin-1 in deeper dermis. In summary, the combination of topical treatment with kinetin and systemic treatment with ITP had complementary beneficial effects in the formation and development of epidermis and dermis.
- MeSH
- Ki-67 Antigen metabolism MeSH
- Administration, Topical MeSH
- Cell Culture Techniques MeSH
- Adult MeSH
- Elastin metabolism MeSH
- Epidermal Cells MeSH
- Epidermis MeSH
- Glycosaminoglycans administration & dosage pharmacology MeSH
- Keratinocytes cytology metabolism MeSH
- Kinetin metabolism MeSH
- Cells, Cultured MeSH
- Skin MeSH
- Drug Interactions MeSH
- Humans MeSH
- Microfilament Proteins metabolism MeSH
- Skin Care MeSH
- Intermediate Filament Proteins analysis metabolism MeSH
- Proteins administration & dosage pharmacology MeSH
- Plant Growth Regulators pharmacology MeSH
- Dermis cytology MeSH
- Skin, Artificial MeSH
- Check Tag
- Adult MeSH
- Humans MeSH
- Female MeSH
- Publication type
- Comparative Study MeSH
[8] s. obr. příl., 442 s. : il. ; 24 cm
