Current challenges and future perspectives in oral absorption research: An opinion of the UNGAP network
Language English Country Netherlands Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't, Review
PubMed
33610694
DOI
10.1016/j.addr.2021.02.001
PII: S0169-409X(21)00035-1
Knihovny.cz E-resources
- Keywords
- Advanced formulations, Amorphous solid dispersions, Food-drug interactions, In vitro tools, Lipid-based formulations, Microbiome, PBPK modeling, Regional differences, Specific patient populations,
- MeSH
- Administration, Oral MeSH
- Gastrointestinal Tract metabolism MeSH
- Food-Drug Interactions MeSH
- Intestinal Absorption * MeSH
- Pharmaceutical Preparations chemistry metabolism MeSH
- Humans MeSH
- Computer Simulation MeSH
- Drug Compounding MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
- Names of Substances
- Pharmaceutical Preparations MeSH
Although oral drug delivery is the preferred administration route and has been used for centuries, modern drug discovery and development pipelines challenge conventional formulation approaches and highlight the insufficient mechanistic understanding of processes critical to oral drug absorption. This review presents the opinion of UNGAP scientists on four key themes across the oral absorption landscape: (1) specific patient populations, (2) regional differences in the gastrointestinal tract, (3) advanced formulations and (4) food-drug interactions. The differences of oral absorption in pediatric and geriatric populations, the specific issues in colonic absorption, the formulation approaches for poorly water-soluble (small molecules) and poorly permeable (peptides, RNA etc.) drugs, as well as the vast realm of food effects, are some of the topics discussed in detail. The identified controversies and gaps in the current understanding of gastrointestinal absorption-related processes are used to create a roadmap for the future of oral drug absorption research.
Abbvie Deutschland GmbH and Co KG Ludwigshafen Germany
Advanced Drug Delivery Pharmaceutical Sciences R and D AstraZeneca Gothenburg Sweden
College of Pharmaceutical Sciences Ritsumeikan University Shiga Japan
Department of Pharmaceutical and Pharmacological Sciences KU Leuven Leuven Belgium
Department of Pharmacology and Toxicology Radboud University Medical Center Nijmegen the Netherlands
Department of Pharmacy and Pharmacology University of Bath Bath United Kingdom
Department of Pharmacy National and Kapodistrian University of Athens Athens Greece
Department of Pharmacy UiT The Arctic University of Norway Tromsø Norway
Department of Pharmacy University of Copenhagen Copenhagen Denmark
Department of Pharmacy Uppsala University Uppsala Sweden
Drug Product Design Pfizer PGRD Sandwich United Kingdom
F Hoffmann La Roche Ltd Basel Switzerland
Faculty of Medicine University of Medicine and Pharmacy of Iasi Romania
Faculty of Pharmacy Charles University Hradec Králové Czech Republic
GlaxoSmithKline Research and Development Ware United Kingdom
INRAE Institut Agro STLO Rennes France
Institute of Microbiology of the Czech Academy of Sciences Prague Czech Republic
Janssen Pharmaceutica NV Beerse Belgium
Lonza Pharma and Biotech Colmar France
Monash Institute of Pharmaceutical Sciences Monash University Parkville Australia
Pharmaceutical Development UCB Pharma SA Braine l'Alleud Belgium
Pharmaceutical Sciences Merck and Co Inc Rahway NJ USA
Physiolution Polska Sp Z o o Wroclaw Poland
School of Food Science and Nutrition University of Leeds Leeds United Kingdom
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