Although oral drug delivery is the preferred administration route and has been used for centuries, modern drug discovery and development pipelines challenge conventional formulation approaches and highlight the insufficient mechanistic understanding of processes critical to oral drug absorption. This review presents the opinion of UNGAP scientists on four key themes across the oral absorption landscape: (1) specific patient populations, (2) regional differences in the gastrointestinal tract, (3) advanced formulations and (4) food-drug interactions. The differences of oral absorption in pediatric and geriatric populations, the specific issues in colonic absorption, the formulation approaches for poorly water-soluble (small molecules) and poorly permeable (peptides, RNA etc.) drugs, as well as the vast realm of food effects, are some of the topics discussed in detail. The identified controversies and gaps in the current understanding of gastrointestinal absorption-related processes are used to create a roadmap for the future of oral drug absorption research.

Abbvie Deutschland GmbH and Co KG Ludwigshafen Germany

Advanced Drug Delivery Pharmaceutical Sciences R and D AstraZeneca Gothenburg Sweden

College of Pharmaceutical Sciences Ritsumeikan University Shiga Japan

Department of Pharmaceutical and Pharmacological Sciences KU Leuven Leuven Belgium

Department of Pharmaceutical and Pharmacological Sciences KU Leuven Leuven Belgium; Department of Chemical and Pharmaceutical Engineering Sofia University Sofia Bulgaria

Department of Pharmaceutical Technology Institute of Pharmacy University of Innsbruck Innsbruck Austria

Department of Pharmacology and Toxicology Radboud University Medical Center Nijmegen the Netherlands

Department of Pharmacy and Pharmacology University of Bath Bath United Kingdom

Department of Pharmacy National and Kapodistrian University of Athens Athens Greece

Department of Pharmacy UiT The Arctic University of Norway Tromsø Norway

Department of Pharmacy University of Copenhagen Copenhagen Denmark

Department of Pharmacy Uppsala University Uppsala Sweden

Drug Product Design Pfizer PGRD Sandwich United Kingdom

F Hoffmann La Roche Ltd Basel Switzerland

Faculty of Medicine University of Medicine and Pharmacy of Iasi Romania

Faculty of Pharmacy Charles University Hradec Králové Czech Republic

Food Colour and Quality Laboratory Area of Nutrition and Food Science Universidad de Sevilla Seville Spain

GlaxoSmithKline Research and Development Ware United Kingdom

INRAE Institut Agro STLO Rennes France

Institute for Pharma Technology University of Applied Sciences and Arts Northwestern Switzerland Basel Switzerland

Institute of Microbiology of the Czech Academy of Sciences Prague Czech Republic

Janssen Pharmaceutica NV Beerse Belgium

Lonza Pharma and Biotech Colmar France

Monash Institute of Pharmaceutical Sciences Monash University Parkville Australia

Oral Product Development Pharmaceutical Technology and Development Operations AstraZeneca Gothenburg Sweden

Pharmaceutical Development UCB Pharma SA Braine l'Alleud Belgium

Pharmaceutical Sciences Merck and Co Inc Rahway NJ USA

Physiolution Polska Sp Z o o Wroclaw Poland

School of Food Science and Nutrition University of Leeds Leeds United Kingdom

School of Pharmacy University College Cork Cork Ireland

Strathclyde Institute of Pharmacy and Biomedical Sciences University of Strathclyde Glasgow United Kingdom

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