Many cognitive functions, including working memory, are processed within large-scale brain networks. We targeted the right frontoparietal network (FPN) with one session of transcranial direct current stimulation (tDCS) in an attempt to modulate the cognitive speed of a visual working memory task (WMT) in 27 young healthy subjects using a double-blind crossover design. We further explored the neural underpinnings of induced changes by performing resting-state fMRI prior to and immediately after each stimulation session with the main focus on the interaction between a task-positive FPN and a task-negative default mode network (DMN). Twenty minutes of 2 mA anodal tDCS was superior to sham stimulation in terms of cognitive speed manipulation of a subtask with processing of objects and tools in unconventional views (i.e., the higher cognitive load subtask of the offline WMT). This result was linked to the magnitude of resting-state functional connectivity decreases between the stimulated FPN seed and DMN seeds. We provide the first evidence for the action reappraisal mechanism of object and tool processing. Modulation of cognitive speed of the task by tDCS was reflected by FPN-DMN cross-talk changes.

1st Department of Neurology Faculty of Medicine Masaryk University and St Anne's University Hospital Brno Czech Republic

Central European Institute of Technology CEITEC Masaryk University Applied Neuroscience Research Group Brno Czech Republic

Central European Institute of Technology CEITEC Masaryk University Multimodal and Functional Neuroimaging Research Group Brno Czech Republic

Faculty of Medicine Masaryk University Brno Czech Republic

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Physiology-inspired bifocal fronto-parietal tACS for working memory enhancement

Exploring the impact of intensified multiple session tDCS over the left DLPFC on brain function in MCI: a randomized control trial

Inter-individual differences in baseline dynamic functional connectivity are linked to cognitive aftereffects of tDCS