Autoantibodies neutralizing type I IFNs are present in ~4% of uninfected individuals over 70 years old and account for ~20% of COVID-19 deaths

. 2021 Aug 19 ; 6 (62) : .

Jazyk angličtina Země Spojené státy americké Médium print

Typ dokumentu časopisecké články, Research Support, N.I.H., Extramural, Research Support, N.I.H., Intramural, práce podpořená grantem

Perzistentní odkaz   https://www.medvik.cz/link/pmid34413139

Grantová podpora
UM1 HG006504 NHGRI NIH HHS - United States
75N91019D00024 NCI NIH HHS - United States
R01 AI091707 NIAID NIH HHS - United States
S10 OD018521 NIH HHS - United States
2U19 AI111825 NIH HHS - United States
ZIA AI001270 Intramural NIH HHS - United States
MR/S032304/1 Medical Research Council - United Kingdom
U19 AI111825 NIAID NIH HHS - United States
R01 AI163029 NIAID NIH HHS - United States
P01 AI138398-S1 NIH HHS - United States
1ZIA AI001265 Intramural NIH HHS - United States
Howard Hughes Medical Institute - United States
UL1 TR001866 NCATS NIH HHS - United States
R01 AI088364 NIAID NIH HHS - United States
R01 AI091707-10S1 NIH HHS - United States
ZIA AI001265 Intramural NIH HHS - United States
U24 HG008956 NHGRI NIH HHS - United States

Circulating autoantibodies (auto-Abs) neutralizing high concentrations (10 ng/mL, in plasma diluted 1 to 10) of IFN-α and/or -ω are found in about 10% of patients with critical COVID-19 pneumonia, but not in subjects with asymptomatic infections. We detect auto-Abs neutralizing 100-fold lower, more physiological, concentrations of IFN-α and/or -ω (100 pg/mL, in 1/10 dilutions of plasma) in 13.6% of 3,595 patients with critical COVID-19, including 21% of 374 patients > 80 years, and 6.5% of 522 patients with severe COVID-19. These antibodies are also detected in 18% of the 1,124 deceased patients (aged 20 days-99 years; mean: 70 years). Moreover, another 1.3% of patients with critical COVID-19 and 0.9% of the deceased patients have auto-Abs neutralizing high concentrations of IFN-β. We also show, in a sample of 34,159 uninfected subjects from the general population, that auto-Abs neutralizing high concentrations of IFN-α and/or -ω are present in 0.18% of individuals between 18 and 69 years, 1.1% between 70 and 79 years, and 3.4% >80 years. Moreover, the proportion of subjects carrying auto-Abs neutralizing lower concentrations is greater in a subsample of 10,778 uninfected individuals: 1% of individuals <70 years, 2.3% between 70 and 80 years, and 6.3% >80 years. By contrast, auto-Abs neutralizing IFN-β do not become more frequent with age. Auto-Abs neutralizing type I IFNs predate SARS-CoV-2 infection and sharply increase in prevalence after the age of 70 years. They account for about 20% of both critical COVID-19 cases in the over-80s, and total fatal COVID-19 cases.

ADMA Biologics Inc Ramsey NJ

Aix Marseille Université IRD APHM MEPHI Marseille France

Aix Marseille University School of Medicine La Timone Medical Campus EA 3279 CEReSS Health Service Research and Quality of Life Center Marseille France

Allergy and Clinical Immunology Unit Department of Medicine Tel Aviv Sourasky Medical Center Tel Aviv Israel

AP HP Bichat Claude Bernard Hospital Infectious and Tropical Diseases Department Paris France

AP HP Département Epidémiologie Biostatistiques et Recherche Clinique Hôpital Bichat Paris France

Avicenne Hospital Assistance Publique Hôpitaux de Paris Bobigny INSERM U1272 Hypoxia and Lung Bobigny France

Bordeaux University Hospital Department of Neurology Institute of Neurodegenerative Diseases F 33000 Bordeaux France

Cancer Genetics and Prevention Program University of California San Francisco San Francisco USA

Catalan Institution for Research and Advanced Studies Barcelona Spain

Center for Autoimmune Disease Research School of Medicine and Health Sciences Universidad del Rosario Bogota Colombia

Center for Clinical Experimental Surgery and Translational Research Biomedical Research Foundation of the Academy of Athens Athens Greece

Centro de Investigación en Red de Enfermedades Respiratorias CIBERES Instituto de Salud Carlos 3 Madrid España

Cerba Health Care Issy les Moulineaux France

Chair of Human Genomics and Evolution Collège de France Paris France

CHU Lille Pôle de Réanimation Hôpital Roger Salengro Lille France

CIBER de Enfermedades Respiratorias Instituto de Salud Carlos 3 Madrid Spain

Clinical Immunology Unit Department of Pediatric Infectious Disease CHU Ibn Rushd and LICIA Laboratoire d'Immunologie Clinique Inflammation et Allergie Faculty of Medicine and Pharmacy Hassan 2 University Casablanca Morocco

CNRS UMR 5308 ENS UCBL Lyon France; National Referee Centre for Rheumatic and Autoimmune and Systemic Diseases in Children Lyon France; Lyon; Immunopathology Federation LIFE Hospices Civils de Lyon Lyon France

CNRS UMR9017 Lille France

College of Medicine Imam Abdulrahman Bin Faisal University Dammam Saudi Arabia

CREA Laboratory Diagnostic Department ASST Spedali Civili di Brescia Brescia Italy

Critical Care Unit University Hospital of Gran Canaria Dr Negrín Canarian Health System Las Palmas de Gran Canaria Canary Islands Spain

Département d'Immunologie Assistance Publique Hôpitaux de Paris Hôpital Pitié Salpétrière Paris France

Department of Age Related Healthcare Tallaght University Hospital and Department of Medical Gerontology School of Medicine Trinity College Dublin

Department of Biomedicine Aarhus University Aarhus Denmark

Department of Biosciences and Nutrition Karolinska Institutet Stockholm Sweden

Department of Children's Diseases and Pediatric Surgery 1 Horbachevsky Ternopil National Medical University Ternopil Ukraine

Department of Clinical Immunology Rigshospitalet Copenhagen University Hospital Copenhagen Denmark

Department of Clinical Laboratory Hospital Universitari de Bellvitge IDIBELL Barcelona Spain

Department of Clinical Sciences University Fernando Pessoa Canarias Las Palmas de Gran Canaria Canary Islands Spain

Department of Critical Care Medicine Clinica Universidad de La Sabana Chia Colombia

Department of Epidemiology Infectious Disease Control and Prevention Graduate School of Biomedical and Health Sciences Hiroshima University Hiroshima Japan

Department of Genetics Yale University School of Medicine New Haven CT USA

Department of Hematology Necker Hospital AP HP Paris France

Department of Immunology 2nd Faculty of Medicine Charles University and University Hospital in Motol Prague Czech Republic

Department of Immunology CIC1408 GIMAP CIRI INSERM U1111 University Hospital of Saint Etienne Saint Etienne France

Department of Immunology Hospital Universitari de Bellvitge IDIBELL Barcelona Spain

Department of Immunology Institute of Biomedical Sciences University of Sao Paulo Sao Paulo Brazil

Department of Infection Control and Prevention Medical Hospital Tokyo Medical and Dental University Tokyo Japan

Department of Infectious Diseases Aarhus University Hospital Skejby Denmark

Department of Infectious Diseases San Gerardo Hospital University of Milano Bicocca Monza Italy

Department of Internal Medicine 2 Medical University of Innsbruck Innsbruck Austria

Department of Internal Medicine Hospital Universitari de Bellvitge IDIBELL Barcelona Spain

Department of Internal Medicine Infanta Leonor University Hospital Madrid Spain

Department of Medical Genetics Acibadem University School of Medicine Istanbul Turkey

Department of Medical Gerontology School of Medicine Trinity College Dublin

Department of Medical Microbiology University Medical Center Utrecht Utrecht Netherlands

Department of Medicine Division of Infectious Diseases McGill University Health Centre Montréal Québec Canada

Department of Microbiology Universidad de La Sabana Chia Colombia

Department of Molecular Biology and Genetics Bilkent University Bilkent Ankara Turkey

Department of Nephrology and Transplantation Necker University Hospital APHP Paris France; INEM INSERM U 1151 CNRS UMR 8253 Paris University Paris France

Department of Neurology Amsterdam Neuroscience Amsterdam Netherlands

Department of Neurosurgery Yale University School of Medicine New Haven CT USA

Department of Paediatric Immunology and Pulmonology Center for Primary Immunodeficiency Ghent Jeffrey Modell Diagnosis and Research Center Ghent University Hospital Ghent Belgium

Department of Paediatrics and Adolescent Medicine The University of Hong Kong Hong Kong China

Department of Pathology and Laboratory Medicine Perelman School of Medicine University of Pennsylvania Philadelphia PA

Department of Pediatrics and Developmental Biology Graduate School of Medical and Dental Sciences Tokyo Medical and Dental University Tokyo Japan

Department of Pediatrics British Columbia Children's Hospital The University of British Columbia Vancouver BC Canada

Department of Pediatrics Fondazione IRCCS Policlinico San Matteo University of Pavia Pavia Italy

Department of Pediatrics Graduate School of Biomedical and Health Sciences Hiroshima University Hiroshima Japan

Department of Pediatrics Jeffrey Modell Diagnostic and Research Network Center University Hospitals Leuven Leuven Belgium

Department of Pediatrics King Fahad Hospital of the University Al Khobar Saudi Arabia

Department of Pharmacology and Molecular Therapeutics Uniformed Services University of the Health Sciences Bethesda MD USA

Diabetes Center University of California San Francisco CA USA

Diabetes Research Institute IRCCS San Raffaele Scientific Institute Milan Italy

Division of Geriatric Medicine Tours University Medical Center Tours France

Dmitry Rogachev National Medical Research Center of Pediatric Hematology Oncology and Immunology Moscow Russia

EA 7426 « Pathophysiology of Injury Induced Immunosuppression » Université Claude Bernard Lyon 1 Hospices Civils de Lyon Hôpital Edouard Herriot BioMérieux Lyon France

Etablissement Français du Sang Auvergne Rhône Alpes St Etienne St Etienne France

Etablissement Français du Sang La Plaine St Denis France

Faculdades Pequeno Príncipe Instituto de Pesquisa Pelé Pequeno Príncipe Curitiba Brazil

Faculty of Medical Sciences University Goce Delchev Stip Republic of Northern Macedonia

Feinstein Institutes for Medical Research Northwell Health Manhasset NY USA

Fundación Rioja Salud Centro de Investigación Biomédica de La Rioja Logrono Spain

Garvan Institute of Medical Research Sydney Australia

Groupe de Recherche Clinique CARMAS Faculté de Santé de Créteil Université Paris Est Créteil 51 Avenue du Maréchal de Lattre de Tassigny 94010 Créteil Cedex France

Hematology and Bone Marrow Transplantation Unit IRCCS San Raffaele Scientific Institute Milano Italy

Hospices Civils de Lyon Lyon France; International Center of Research in Infectiology Lyon University INSERM U1111 CNRS UMR 5308 ENS UCBL Lyon France

Hospital Universitari Mutua Tarrassa Tarrasa Spain

Hospital Universitario de Gran Canaria Dr Negrín Canarian Health System Canary Islands Spain

Howard Hughes Medical Institute New York NY USA

Human Evolutionary Genetics Unit Institut Pasteur CNRS UMR 2000 Paris France

IHU Méditerranée Infection Unité des Virus Émergents UVE Aix Marseille University IRD 190 INSERM 1207 Marseille France

Imagine Institute Université de Paris INSERM UMR 1163 Paris France

Immunology Division Genetics Department Hospital Universitari Vall d'Hebron Vall d'Hebron Research Institute Vall d'Hebron Barcelona Hospital Campus UAB Barcelona Catalonia Spain

Infectious Disease Susceptibility Program Research Institute McGill University Health Centre Montréal Québec Canada

Infectious Diseases and Immunity Center for Health and Social Care Research Vic Spain

Inserm CIC 1425 Paris France

INSERM U1019 Lille France

INSERM U1138 Centre de Recherche des Cordeliers Paris France

INSERM U1259 MAVIVH Université de Tours Tours France

INSERM UMRS_1166 iCAN Institute of Cardiometabolism and Nutrition Paris France

Institut d'Investigacions Biomèdiques August Pi i Sunyer Barcelona Spain

Institut Hospitalo Universitaire Méditerranée Infection Marseille France

Institut Pasteur de Lille Lille France

Institute for Biomedical Research Spanish Research Council Barcelona Spain

Institute for Systems Biology Seattle WA 98109 USA

Institute of Biomedicine and Translational Medicine University of Tartu Tartu Estonia

Institute of public health of Republic of North Macedonia

Intensive Care Department Donostia University Hospital San Sebastian Spain

Intensive Care Unit Grand Hôpital de l'Est Francilien Site de Marne la Vallée Jossigny France

Internal Medicine Department Lariboisière Hospital AP HP Paris University Paris France

IrsiCaixa AIDS Research Institute and Institute for Health Science Research Germans Trias i Pujol Badalona Spain

Joint Research Unit Hospices Civils de Lyon bio Mérieux Hospices Civils de Lyon Lyon Sud Hospital Pierre Bénite France; International Center of Research in Infectiology Lyon University INSERM U1111 CNRS UMR 5308 ENS UCBL Lyon France

Laboratoire d'Immunologie Hospices Civils de Lyon Hôpital Edouard Herriot Lyon France

Laboratory of Clinical Immunology and Microbiology Division of Intramural Research NIAID NIH Bethesda MD USA

Laboratory of Human Genetics and Genomics The Rockefeller University New York NY

Laboratory of Human Genetics of Infectious Diseases Necker Branch INSERM U1163 Necker Hospital for Sick Children Paris France

Laboratory of Immunobiology Center for Clinical Experimental Surgery and Translational Research Biomedical Research Foundation of the Academy of Athens 11527 Athens Greece

Laboratory of Inborn Errors of Immunity Department of Immunology Microbiology and Transplantation KU Leuven Leuven Belgium

Laboratory of Molecular Immunology Rockefeller University New York NY USA

Laboratory of Virology and Infectious Disease The Rockefeller University New York NY USA

Medical Intensive care Unit University Hospitals Leuven Leuven Belgium

Meram Medical Faculty Necmettin Erbakan University Meram Medical Faculty Konya Turkey

Neurometabolic Diseases Laboratory IDIBELL Hospital Duran i Reynals CIBERER U759 and Catalan Institution of Research and Advanced Studies Barcelona Spain

NIAID Clinical Genomics Program National Institutes of Health Bethesda USA

Paris Cardiovascular Center PARCC Inserm Université de Paris Paris France

Pathogenesis and Therapy of Primary Immunodeficiencies Unit San Raffaele Milano Italy

Pediatric Department and Centro Tettamanti European Reference Network PaedCan EuroBloodNet MetabERN University of Milano Bicocca Fondazione MBBM Ospedale San Gerardo Monza Italy

Pediatric Infectious Diseases and Immunodeficiencies Unit Hospital Universitari Vall d'Hebron Vall d'Hebron Research Institute Vall d'Hebron Barcelona Hospital Campus Universitat Autònoma de Barcelona Barcelona Catalonia Spain

Precision Medicine Unit Lausanne University Hospital and University of Lausanne Lausanne Switzerland

Primary Immunodeficiencies Group Department of Microbiology and Parasitology School of Medicine University of Antioquia UDEA Medellín Colombia

Primary Immunodeficiencies Group University of Antioquia UdeA Medellin Colombia

Réanimation Médicale et Toxicologique Hôpital Lariboisière 1144

Sackler Faculty of Medicine Tel Aviv University Tel Aviv Israel

SAINBIOSE INSERM U1059 University of Lyon Université Jean Monnet Saint Etienne

School of Life Sciences Ecole Polytechnique Fédérale de Lausanne Lausanne Switzerland

School of Microbiology University of Antioquia UdeA Medellin Colombia

Service d'Evaluation Médicale Hôpitaux Universitaires de Marseille Assistance Publique Hôpitaux de Marseille Marseille France

Service d'Hématologie Biologique Hôpital Lariboisière Assistance Publique Hôpitaux de Paris and EA3518 Institut Universitaire d'Hématologie Hôpital Saint Louis Université Paris Diderot Paris France

Service de Bactériologie Virologie Hygiène CHU de Tours Tours France

Service de Biologie Clinique and UMR S 1176 Hopital Foch Suresnes France

Service de Biologie Médicale CHI Robert Ballanger Aulnay sous Bois France

Service de Médecine Intensive Réanimation Hôpitaux Universitaires Henri Mondor Assistance Publique Hôpitaux de Paris

Service de Médecine Interne Hôpital universitaire Jean Verdier AP HP Bondy France

Service de Parasitologie Mycologie Groupe Hospitalier Pitié Salpêtrière AP HP Paris France

Sharjah Institute for Medical Research College of Medicine University of Sharjah Sharjah United Arab Emirates

Shupyk National Healthcare University of Ukraine Kyiv Ukraine

Sorbonne Université Assistance Publique Hôpitaux de Paris Hôpital Pitié Salpêtrière Médecine Intensive Réanimation AP HP Paris France

Sorbonne Université Inserm Centre d'Immunologie et des Maladies Infectieuses Paris France

Sorbonne Université INSERM U1136 Institut Pierre Louis d'Epidémiologie et de Santé Publique AP HP Hôpital Pitié Salpêtrière Service de Virologie Paris France

St Giles Laboratory of Human Genetics of Infectious Diseases Rockefeller Branch The Rockefeller University New York NY USA

Swiss Institue of Bioinformatics Lausanne Switzerland

The Genetics Institute Tel Aviv Sourasky Medical Center Tel Aviv University Tel Aviv Israel

Translational Immunology Lab Institut Pasteur

UMR 1098 RIGHT Inserm EFS Université de Franche Comté Besançon France

Université de Lille Inserm CHU Lille Institut Pasteur de Lille U1011 EGID F 59000 Lille France

Université de Paris IAME UMR S 1137 INSERM Paris France

Université de Paris Université Paris Saclay UVSQ Inserm UMS11 Villejuif France

University of Bordeaux INSERM Bordeaux Population Health Center UMR1219 F 33000 Bordeaux France

University of Lille U1019 UMR9017 Center for Infection and Immunity of Lille Lille France

University of Paris Imagine Institute Paris France

University of Sao Paulo Sao Paulo Brazil

Yale Center for Genome Analysis Yale School of Medicine New Haven CT USA

Komentář v

PubMed

Komentář v

PubMed

Komentář v

PubMed

Zobrazit více v PubMed

Levin A. T., Hanage W. P., Owusu-Boaitey N., Cochran K. B., Walsh S. P., Meyerowitz-Katz G., Assessing the age specificity of infection fatality rates for COVID-19: Systematic review, meta-analysis, and public policy implications. Eur. J. Epidemiol. 35, 1123–1138 (2020). 10.1007/s10654-020-00698-1 PubMed DOI PMC

O’Driscoll M., Ribeiro Dos Santos G., Wang L., Cummings D. A. T., Azman A. S., Paireau J., Fontanet A., Cauchemez S., Salje H., Age-specific mortality and immunity patterns of SARS-CoV-2. Nature 590, 140–145 (2021). 10.1038/s41586-020-2918-0 PubMed DOI

Williamson E. J., Walker A. J., Bhaskaran K., Bacon S., Bates C., Morton C. E., Curtis H. J., Mehrkar A., Evans D., Inglesby P., Cockburn J., McDonald H. I., MacKenna B., Tomlinson L., Douglas I. J., Rentsch C. T., Mathur R., Wong A. Y. S., Grieve R., Harrison D., Forbes H., Schultze A., Croker R., Parry J., Hester F., Harper S., Perera R., Evans S. J. W., Smeeth L., Goldacre B., Factors associated with COVID-19-related death using OpenSAFELY. Nature 584, 430–436 (2020). 10.1038/s41586-020-2521-4 PubMed DOI PMC

Brodin P., Immune determinants of COVID-19 disease presentation and severity. Nat. Med. 27, 28–33 (2021). 10.1038/s41591-020-01202-8 PubMed DOI

Zhang Q., Bastard P., Bolze A., Jouanguy E., Zhang S. Y., Cobat A., Notarangelo L. D., Su H. C., Abel L., Casanova J. L.; COVID Human Genetic Effort , Life-Threatening COVID-19: Defective Interferons Unleash Excessive Inflammation. Med (N Y) 1, 14–20 (2020). PubMed PMC

Casanova J. L., Su H. C.; COVID Human Genetic Effort , A Global Effort to Define the Human Genetics of Protective Immunity to SARS-CoV-2 Infection. Cell 181, 1194–1199 (2020). 10.1016/j.cell.2020.05.016 PubMed DOI PMC

Zhang Q., Bastard P., Liu Z., Le Pen J., Moncada-Velez M., Chen J., Ogishi M., Sabli I. K. D., Hodeib S., Korol C., Rosain J., Bilguvar K., Ye J., Bolze A., Bigio B., Yang R., Arias A. A., Zhou Q., Zhang Y., Onodi F., Korniotis S., Karpf L., Philippot Q., Chbihi M., Bonnet-Madin L., Dorgham K., Smith N., Schneider W. M., Razooky B. S., Hoffmann H.-H., Michailidis E., Moens L., Han J. E., Lorenzo L., Bizien L., Meade P., Neehus A.-L., Ugurbil A. C., Corneau A., Kerner G., Zhang P., Rapaport F., Seeleuthner Y., Manry J., Masson C., Schmitt Y., Schlüter A., Le Voyer T., Khan T., Li J., Fellay J., Roussel L., Shahrooei M., Alosaimi M. F., Mansouri D., Al-Saud H., Al-Mulla F., Almourfi F., Al-Muhsen S. Z., Alsohime F., Al Turki S., Hasanato R., van de Beek D., Biondi A., Bettini L. R., D’Angio’ M., Bonfanti P., Imberti L., Sottini A., Paghera S., Quiros-Roldan E., Rossi C., Oler A. J., Tompkins M. F., Alba C., Vandernoot I., Goffard J.-C., Smits G., Migeotte I., Haerynck F., Soler-Palacin P., Martin-Nalda A., Colobran R., Morange P.-E., Keles S., Çölkesen F., Ozcelik T., Yasar K. K., Senoglu S., Karabela Ş. N., Rodríguez-Gallego C., Novelli G., Hraiech S., Tandjaoui-Lambiotte Y., Duval X., Laouénan C., Snow A. L., Dalgard C. L., Milner J. D., Vinh D. C., Mogensen T. H., Marr N., Spaan A. N., Boisson B., Boisson-Dupuis S., Bustamante J., Puel A., Ciancanelli M. J., Meyts I., Maniatis T., Soumelis V., Amara A., Nussenzweig M., García-Sastre A., Krammer F., Pujol A., Duffy D., Lifton R. P., Zhang S.-Y., Gorochov G., Béziat V., Jouanguy E., Sancho-Shimizu V., Rice C. M., Abel L., Notarangelo L. D., Cobat A., Su H. C., Casanova J.-L.; COVID-STORM Clinicians; COVID Clinicians; Imagine COVID Group; French COVID Cohort Study Group; CoV-Contact Cohort; Amsterdam UMC Covid-19 Biobank; COVID Human Genetic Effort; NIAID-USUHS/TAGC COVID Immunity Group , Inborn errors of type I IFN immunity in patients with life-threatening COVID-19. Science 370, eabd4570 (2020). 10.1126/science.abd4570 PubMed DOI PMC

Novelli G., Biancolella M., Mehrian-Shai R., Colona V. L., Brito A. F., Grubaugh N. D., Vasiliou V., Luzzatto L., Reichardt J. K. V., COVID-19 one year into the pandemic: From genetics and genomics to therapy, vaccination, and policy. Hum. Genomics 15, 27 (2021). 10.1186/s40246-021-00326-3 PubMed DOI PMC

Bastard P., Rosen L. B., Zhang Q., Michailidis E., Hoffmann H.-H., Zhang Y., Dorgham K., Philippot Q., Rosain J., Béziat V., Manry J., Shaw E., Haljasmägi L., Peterson P., Lorenzo L., Bizien L., Trouillet-Assant S., Dobbs K., de Jesus A. A., Belot A., Kallaste A., Catherinot E., Tandjaoui-Lambiotte Y., Le Pen J., Kerner G., Bigio B., Seeleuthner Y., Yang R., Bolze A., Spaan A. N., Delmonte O. M., Abers M. S., Aiuti A., Casari G., Lampasona V., Piemonti L., Ciceri F., Bilguvar K., Lifton R. P., Vasse M., Smadja D. M., Migaud M., Hadjadj J., Terrier B., Duffy D., Quintana-Murci L., van de Beek D., Roussel L., Vinh D. C., Tangye S. G., Haerynck F., Dalmau D., Martinez-Picado J., Brodin P., Nussenzweig M. C., Boisson-Dupuis S., Rodríguez-Gallego C., Vogt G., Mogensen T. H., Oler A. J., Gu J., Burbelo P. D., Cohen J. I., Biondi A., Bettini L. R., D’Angio M., Bonfanti P., Rossignol P., Mayaux J., Rieux-Laucat F., Husebye E. S., Fusco F., Ursini M. V., Imberti L., Sottini A., Paghera S., Quiros-Roldan E., Rossi C., Castagnoli R., Montagna D., Licari A., Marseglia G. L., Duval X., Ghosn J., Tsang J. S., Goldbach-Mansky R., Kisand K., Lionakis M. S., Puel A., Zhang S.-Y., Holland S. M., Gorochov G., Jouanguy E., Rice C. M., Cobat A., Notarangelo L. D., Abel L., Su H. C., Casanova J.-L.; HGID Lab; NIAID-USUHS Immune Response to COVID Group; COVID Clinicians; COVID-STORM Clinicians; Imagine COVID Group; French COVID Cohort Study Group; Milieu Intérieur Consortium; CoV-Contact Cohort; Amsterdam UMC Covid-19 Biobank; COVID Human Genetic Effort , Autoantibodies against type I IFNs in patients with life-threatening COVID-19. Science 370, eabd4585 (2020). 10.1126/science.abd4585 PubMed DOI PMC

Lazear H. M., Schoggins J. W., Diamond M. S., Shared and Distinct Functions of Type I and Type III Interferons. Immunity 50, 907–923 (2019). 10.1016/j.immuni.2019.03.025 PubMed DOI PMC

Koning R., Bastard P., Casanova J.-L., Brouwer M. C., van de Beek D.; with the Amsterdam U.M.C. COVID-19 Biobank Investigators , Autoantibodies against type I interferons are associated with multi-organ failure in COVID-19 patients. Intensive Care Med. 47, 704–706 (2021). 10.1007/s00134-021-06392-4 PubMed DOI PMC

Troya J., Bastard P., Planas-Serra L., Ryan P., Ruiz M., de Carranza M., Torres J., Martínez A., Abel L., Casanova J.-L., Pujol A., Neutralizing Autoantibodies to Type I IFNs in >10% of Patients with Severe COVID-19 Pneumonia Hospitalized in Madrid, Spain. J. Clin. Immunol. 41, 914–922 (2021). 10.1007/s10875-021-01036-0 PubMed DOI PMC

Vazquez S. E., Bastard P., Kelly K., Gervais A., Norris P. J., Dumont L. J., Casanova J.-L., Anderson M. S., DeRisi J. L., Neutralizing Autoantibodies to Type I Interferons in COVID-19 Convalescent Donor Plasma. J. Clin. Immunol. 41, 1169–1171 (2021). 10.1007/s10875-021-01060-0 PubMed DOI PMC

Goncalves D., et al. ., Antibodies against type-I Interferon: detection and association with severe clinical outcome in COVID-19 patients. medRxiv, (2021). PubMed PMC

Wang E. Y., Mao T., Klein J., Dai Y., Huck J. D., Jaycox J. R., Liu F., Zhou T., Israelow B., Wong P., Coppi A., Lucas C., Silva J., Oh J. E., Song E., Perotti E. S., Zheng N. S., Fischer S., Campbell M., Fournier J. B., Wyllie A. L., Vogels C. B. F., Ott I. M., Kalinich C. C., Petrone M. E., Watkins A. E., Dela Cruz C., Farhadian S. F., Schulz W. L., Ma S., Grubaugh N. D., Ko A. I., Iwasaki A., Ring A. M.; Yale IMPACT Team , Diverse functional autoantibodies in patients with COVID-19. Nature 595, 283–288 (2021). 10.1038/s41586-021-03631-y PubMed DOI

van der Wijst M. G. P., et al. ., Longitudinal single-cell epitope and RNA-sequencing reveals the immunological impact of type 1 interferon autoantibodies in critical COVID-19. bioRxiv, (2021).

Levin M., Anti-interferon auto-antibodies in autoimmune polyendocrinopathy syndrome type 1. PLOS Med. 3, e292 (2006). 10.1371/journal.pmed.0030292 PubMed DOI PMC

Meager A., Visvalingam K., Peterson P., Möll K., Murumägi A., Krohn K., Eskelin P., Perheentupa J., Husebye E., Kadota Y., Willcox N., Anti-interferon autoantibodies in autoimmune polyendocrinopathy syndrome type 1. PLOS Med. 3, e289 (2006). 10.1371/journal.pmed.0030289 PubMed DOI PMC

Meyer S., Woodward M., Hertel C., Vlaicu P., Haque Y., Kärner J., Macagno A., Onuoha S. C., Fishman D., Peterson H., Metsküla K., Uibo R., Jäntti K., Hokynar K., Wolff A. S. B., Krohn K., Ranki A., Peterson P., Kisand K., Hayday A.; APECED patient collaborative , AIRE-Deficient Patients Harbor Unique High-Affinity Disease-Ameliorating Autoantibodies. Cell 166, 582–595 (2016). 10.1016/j.cell.2016.06.024 PubMed DOI PMC

Bastard P., Orlova E., Sozaeva L., Lévy R., James A., Schmitt M. M., Ochoa S., Kareva M., Rodina Y., Gervais A., Le Voyer T., Rosain J., Philippot Q., Neehus A.-L., Shaw E., Migaud M., Bizien L., Ekwall O., Berg S., Beccuti G., Ghizzoni L., Thiriez G., Pavot A., Goujard C., Frémond M.-L., Carter E., Rothenbuhler A., Linglart A., Mignot B., Comte A., Cheikh N., Hermine O., Breivik L., Husebye E. S., Humbert S., Rohrlich P., Coaquette A., Vuoto F., Faure K., Mahlaoui N., Kotnik P., Battelino T., Trebušak Podkrajšek K., Kisand K., Ferré E. M. N., DiMaggio T., Rosen L. B., Burbelo P. D., McIntyre M., Kann N. Y., Shcherbina A., Pavlova M., Kolodkina A., Holland S. M., Zhang S.-Y., Crow Y. J., Notarangelo L. D., Su H. C., Abel L., Anderson M. S., Jouanguy E., Neven B., Puel A., Casanova J.-L., Lionakis M. S., Preexisting autoantibodies to type I IFNs underlie critical COVID-19 pneumonia in patients with APS-1. J. Exp. Med. 218, e20210554 (2021). 10.1084/jem.20210554 PubMed DOI PMC

Meisel C., Akbil B., Meyer T., Lankes E., Corman V. M., Staudacher O., Unterwalder N., Kölsch U., Drosten C., Mall M. A., Kallinich T., Schnabel D., Goffinet C., von Bernuth H., Mild COVID-19 despite autoantibodies against type I IFNs in autoimmune polyendocrine syndrome type 1. J. Clin. Invest. 131, e150867 (2021). 10.1172/JCI150867 PubMed DOI PMC

Walter J. E., Rosen L. B., Csomos K., Rosenberg J. M., Mathew D., Keszei M., Ujhazi B., Chen K., Lee Y. N., Tirosh I., Dobbs K., Al-Herz W., Cowan M. J., Puck J., Bleesing J. J., Grimley M. S., Malech H., De Ravin S. S., Gennery A. R., Abraham R. S., Joshi A. Y., Boyce T. G., Butte M. J., Nadeau K. C., Balboni I., Sullivan K. E., Akhter J., Adeli M., El-Feky R. A., El-Ghoneimy D. H., Dbaibo G., Wakim R., Azzari C., Palma P., Cancrini C., Capuder K., Condino-Neto A., Costa-Carvalho B. T., Oliveira J. B., Roifman C., Buchbinder D., Kumanovics A., Franco J. L., Niehues T., Schuetz C., Kuijpers T., Yee C., Chou J., Masaad M. J., Geha R., Uzel G., Gelman R., Holland S. M., Recher M., Utz P. J., Browne S. K., Notarangelo L. D., Broad-spectrum antibodies against self-antigens and cytokines in RAG deficiency. J. Clin. Invest. 125, 4135–4148 (2015). 10.1172/JCI80477 PubMed DOI PMC

Rosenberg J. M., Maccari M. E., Barzaghi F., Allenspach E. J., Pignata C., Weber G., Torgerson T. R., Utz P. J., Bacchetta R., Neutralizing Anti-Cytokine Autoantibodies Against Interferon-α in Immunodysregulation Polyendocrinopathy Enteropathy X-Linked. Front. Immunol. 9, 544 (2018). 10.3389/fimmu.2018.00544 PubMed DOI PMC

Vallbracht A., Treuner J., Flehmig B., Joester K. E., Niethammer D., Interferon-neutralizing antibodies in a patient treated with human fibroblast interferon. Nature 289, 496–497 (1981). 10.1038/289496a0 PubMed DOI

Rudick R. A., Simonian N. A., Alam J. A., Campion M., Scaramucci J. O., Jones W., Coats M. E., Goodkin D. E., Weinstock-Guttman B., Herndon R. M., Mass M. K., Richert J. R., Salazar A. M., Munschauer F. E. 3rd, Cookfair D. L., Simon J. H., Jacobs L. D.; Multiple Sclerosis Collaborative Research Group (MSCRG) , Incidence and significance of neutralizing antibodies to interferon beta-1a in multiple sclerosis. Neurology 50, 1266–1272 (1998). 10.1212/WNL.50.5.1266 PubMed DOI

Panem S., Check I. J., Henriksen D., Vilcek J., Antibodies to alpha-interferon in a patient with systemic lupus erythematosus. J. Immunol. 129, 1–3 (1982). PubMed

Gupta S., Tatouli I. P., Rosen L. B., Hasni S., Alevizos I., Manna Z. G., Rivera J., Jiang C., Siegel R. M., Holland S. M., Moutsopoulos H. M., Browne S. K., Distinct Functions of Autoantibodies Against Interferon in Systemic Lupus Erythematosus: A Comprehensive Analysis of Anticytokine Autoantibodies in Common Rheumatic Diseases. Arthritis Rheumatol. 68, 1677–1687 (2016). 10.1002/art.39607 PubMed DOI PMC

Shiono H., Wong Y. L., Matthews I., Liu J. L., Zhang W., Sims G., Meager A., Beeson D., Vincent A., Willcox N., Spontaneous production of anti-IFN-alpha and anti-IL-12 autoantibodies by thymoma cells from myasthenia gravis patients suggests autoimmunization in the tumor. Int. Immunol. 15, 903–913 (2003). 10.1093/intimm/dxg088 PubMed DOI

Bello-Rivero I., Cervantes M., Torres Y., Ferrero J., Rodríguez E., Pérez J., García I., Díaz G., López-Saura P., Characterization of the immunoreactivity of anti-interferon alpha antibodies in myasthenia gravis patients. Epitope mapping. J. Autoimmun. 23, 63–73 (2004). 10.1016/j.jaut.2004.03.013 PubMed DOI

Meager A., Wadhwa M., Dilger P., Bird C., Thorpe R., Newsom-Davis J., Willcox N., Anti-cytokine autoantibodies in autoimmunity: Preponderance of neutralizing autoantibodies against interferon-alpha, interferon-omega and interleukin-12 in patients with thymoma and/or myasthenia gravis. Clin. Exp. Immunol. 132, 128–136 (2003). 10.1046/j.1365-2249.2003.02113.x PubMed DOI PMC

Bastard P., Michailidis E., Hoffmann H.-H., Chbihi M., Le Voyer T., Rosain J., Philippot Q., Seeleuthner Y., Gervais A., Materna M., de Oliveira P. M. N., Maia M. L. S., Dinis Ano Bom A. P., Azamor T., Araújo da Conceição D., Goudouris E., Homma A., Slesak G., Schäfer J., Pulendran B., Miller J. D., Huits R., Yang R., Rosen L. B., Bizien L., Lorenzo L., Chrabieh M., Erazo L. V., Rozenberg F., Jeljeli M. M., Béziat V., Holland S. M., Cobat A., Notarangelo L. D., Su H. C., Ahmed R., Puel A., Zhang S.-Y., Abel L., Seligman S. J., Zhang Q., MacDonald M. R., Jouanguy E., Rice C. M., Casanova J.-L., Auto-antibodies to type I IFNs can underlie adverse reactions to yellow fever live attenuated vaccine. J. Exp. Med. 218, e20202486 (2021). 10.1084/jem.20202486 PubMed DOI PMC

Hadjadj J., Yatim N., Barnabei L., Corneau A., Boussier J., Smith N., Péré H., Charbit B., Bondet V., Chenevier-Gobeaux C., Breillat P., Carlier N., Gauzit R., Morbieu C., Pène F., Marin N., Roche N., Szwebel T.-A., Merkling S. H., Treluyer J.-M., Veyer D., Mouthon L., Blanc C., Tharaux P.-L., Rozenberg F., Fischer A., Duffy D., Rieux-Laucat F., Kernéis S., Terrier B., Impaired type I interferon activity and inflammatory responses in severe COVID-19 patients. Science 369, 718–724 (2020). 10.1126/science.abc6027 PubMed DOI PMC

Trouillet-Assant S., Viel S., Gaymard A., Pons S., Richard J.-C., Perret M., Villard M., Brengel-Pesce K., Lina B., Mezidi M., Bitker L., Belot A.; COVID HCL Study group , Type I IFN immunoprofiling in COVID-19 patients. J. Allergy Clin. Immunol. 146, 206–208.e2 (2020). 10.1016/j.jaci.2020.04.029 PubMed DOI PMC

Honda N., Lindberg U., Andersson P., Hoffmann S., Takei H., Simultaneous multiple immunoassays in a compact disc-shaped microfluidic device based on centrifugal force. Clin. Chem. 51, 1955–1961 (2005). 10.1373/clinchem.2005.053348 PubMed DOI

M. G. P. v. d. Wijst et al., Longitudinal single-cell epitope and RNA-sequencing reveals the immunological impact of type 1 interferon autoantibodies in critical COVID-19. Submitted (2021).

Asano T., et al. ., X-linked recessive TLR7 deficiency in 1% of men under 60 years with life-threatening COVID-19. Sci. Immunol. 6, eabl4348 (2021). PubMed PMC

Bastard P., Lévy R., Henriquez S., Bodemer C., Szwebel T.-A., Casanova J.-L., Interferon-β Therapy in a Patient with Incontinentia Pigmenti and Autoantibodies against Type I IFNs Infected with SARS-CoV-2. J. Clin. Immunol. 41, 931–933 (2021). 10.1007/s10875-021-01023-5 PubMed DOI PMC

Monk P. D., Marsden R. J., Tear V. J., Brookes J., Batten T. N., Mankowski M., Gabbay F. J., Davies D. E., Holgate S. T., Ho L.-P., Clark T., Djukanovic R., Wilkinson T. M. A.; Inhaled Interferon Beta COVID-19 Study Group , Safety and efficacy of inhaled nebulised interferon beta-1a (SNG001) for treatment of SARS-CoV-2 infection: A randomised, double-blind, placebo-controlled, phase 2 trial. Lancet Respir. Med. 9, 196–206 (2021). 10.1016/S2213-2600(20)30511-7 PubMed DOI PMC

Hooper B., Whittingham S., Mathews J. D., Mackay I. R., Curnow D. H., Autoimmunity in a rural community. Clin. Exp. Immunol. 12, 79–87 (1972). PubMed PMC

Shu S., Nisengard R. J., Hale W. L., Beutner E. H., Incidence and titers of antinuclear, antismooth muscle, and other autoantibodies in blood donors. J. Lab. Clin. Med. 86, 259–265 (1975). PubMed

Potocka-Płazak K., Pituch-Noworolska A., Kocemba J., [Prevalence of autoantibodies in serum of healthy persons over 85 years of age]. Przegl. Lek. 52, 544–546 (1995) [Prevalence of autoantibodies in serum of healthy persons over 85 years of age]. PubMed

Parks C. G., Miller F. W., Satoh M., Chan E. K. L., Andrushchenko Z., Birnbaum L. S., Jusko T. A., Kissling G. E., Patel M. D., Rose K. M., Weinberg C., Zeldin D. C., Sandler D. P., Reproductive and hormonal risk factors for antinuclear antibodies (ANA) in a representative sample of U.S. women. Cancer Epidemiol. Biomarkers Prev. 23, 2492–2502 (2014). 10.1158/1055-9965.EPI-14-0429 PubMed DOI PMC

Myasoedova E., Davis J., Matteson E. L., Crowson C. S., Is the epidemiology of rheumatoid arthritis changing? Results from a population-based incidence study, 1985-2014. Ann. Rheum. Dis. 79, 440–444 (2020). 10.1136/annrheumdis-2019-216694 PubMed DOI PMC

Sanchez-Felipe L., Vercruysse T., Sharma S., Ma J., Lemmens V., Van Looveren D., Arkalagud Javarappa M. P., Boudewijns R., Malengier-Devlies B., Liesenborghs L., Kaptein S. J. F., De Keyzer C., Bervoets L., Debaveye S., Rasulova M., Seldeslachts L., Li L.-H., Jansen S., Yakass M. B., Verstrepen B. E., Böszörményi K. P., Kiemenyi-Kayere G., van Driel N., Quaye O., Zhang X., Ter Horst S., Mishra N., Deboutte W., Matthijnssens J., Coelmont L., Vandermeulen C., Heylen E., Vergote V., Schols D., Wang Z., Bogers W., Kuiken T., Verschoor E., Cawthorne C., Van Laere K., Opdenakker G., Vande Velde G., Weynand B., Teuwen D. E., Matthys P., Neyts J., Jan Thibaut H., Dallmeier K., A single-dose live-attenuated YF17D-vectored SARS-CoV-2 vaccine candidate. Nature 590, 320–325 (2021). 10.1038/s41586-020-3035-9 PubMed DOI

Chen P., Nirula A., Heller B., Gottlieb R. L., Boscia J., Morris J., Huhn G., Cardona J., Mocherla B., Stosor V., Shawa I., Adams A. C., Van Naarden J., Custer K. L., Shen L., Durante M., Oakley G., Schade A. E., Sabo J., Patel D. R., Klekotka P., Skovronsky D. M.; BLAZE-1 Investigators , SARS-CoV-2 Neutralizing Antibody LY-CoV555 in Outpatients with Covid-19. N. Engl. J. Med. 384, 229–237 (2021). 10.1056/NEJMoa2029849 PubMed DOI PMC

Weinreich D. M., Sivapalasingam S., Norton T., Ali S., Gao H., Bhore R., Musser B. J., Soo Y., Rofail D., Im J., Perry C., Pan C., Hosain R., Mahmood A., Davis J. D., Turner K. C., Hooper A. T., Hamilton J. D., Baum A., Kyratsous C. A., Kim Y., Cook A., Kampman W., Kohli A., Sachdeva Y., Graber X., Kowal B., DiCioccio T., Stahl N., Lipsich L., Braunstein N., Herman G., Yancopoulos G. D.; Trial Investigators , REGN-COV2, a Neutralizing Antibody Cocktail, in Outpatients with Covid-19. N. Engl. J. Med. 384, 238–251 (2021). 10.1056/NEJMoa2035002 PubMed DOI PMC

de Prost N., Bastard P., Arrestier R., Fourati S., Mahévas M., Burrel S., Dorgham K., Gorochov G., Tandjaoui-Lambiotte Y., Azzaoui I., Fernandes I., Combes A., Casanova J.-L., Mekontso-Dessap A., Luyt C.-E., Plasma Exchange to Rescue Patients with Autoantibodies Against Type I Interferons and Life-Threatening COVID-19 Pneumonia. J. Clin. Immunol. 41, 536–544 (2021). 10.1007/s10875-021-00994-9 PubMed DOI PMC

Vinh D. C., Abel L., Bastard P., Cheng M. P., Condino-Neto A., Gregersen P. K., Haerynck F., Cicalese M. P., Hagin D., Soler-Palacín P., Planas A. M., Pujol A., Notarangelo L. D., Zhang Q., Su H. C., Casanova J. L., Meyts I.; COVID Human Genetic Effort , Harnessing type I IFN immunity against SARS-CoV-2 with early administration of IFN-beta. JoCI, in press (2021). PubMed PMC

Firth D., Bias reduction of maximum likelihood estimates. Biometrika 80, 27–38 (1993). 10.1093/biomet/80.1.27 DOI

Heinze G., Schemper M., A solution to the problem of separation in logistic regression. Stat. Med. 21, 2409–2419 (2002). 10.1002/sim.1047 PubMed DOI

Agresti A., Coull B. A., Approximate is better than “exact” for interval estimation of binomial proportions. Am. Stat. 52, 119–126 (1998).

Najít záznam

Citační ukazatele

Nahrávání dat ...

Možnosti archivace

Nahrávání dat ...