The Kidney Disease: Improving Global Outcomes (KDIGO) Clinical Practice Guideline for the Management of Glomerular Diseases is an update to the KDIGO 2012 guideline. The aim is to assist clinicians caring for individuals with glomerulonephritis (GN), both adults and children. The scope includes various glomerular diseases, including IgA nephropathy and IgA vasculitis, membranous nephropathy, nephrotic syndrome, minimal change disease (MCD), focal segmental glomerulosclerosis (FSGS), infection-related GN, antineutrophil cytoplasmic antibody (ANCA) vasculitis, lupus nephritis, and anti-glomerular basement membrane antibody GN. In addition, this guideline will be the first to address the subtype of complement-mediated diseases. Each chapter follows the same format providing guidance related to diagnosis, prognosis, treatment, and special situations. The goal of the guideline is to generate a useful resource for clinicians and patients by providing actionable recommendations based on evidence syntheses, with useful infographics incorporating views from experts in the field. Another aim is to propose research recommendations for areas where there are gaps in knowledge. The guideline targets a broad global audience of clinicians treating GN while being mindful of implications for policy and cost. Development of this guideline update followed an explicit process whereby treatment approaches and guideline recommendations are based on systematic reviews of relevant studies, and appraisal of the quality of the evidence and the strength of recommendations followed the "Grading of Recommendations Assessment, Development and Evaluation" (GRADE) approach. Limitations of the evidence are discussed, with areas of future research also presented.

Cochrane Kidney and Transplant Sydney New South Wales Australia; Sydney School of Public Health The University of Sydney Sydney New South Wales Australia

College of Medicine and Public Health Flinders University Adelaide Australia; Cochrane Kidney and Transplant Sydney New South Wales Australia

Department of Cardiovascular Sciences University of Leicester Leicester UK

Department of Internal Medicine The Ohio State University College of Medicine Columbus Ohio USA

Department of Laboratory Medicine and Pathology Mayo Clinic Rochester Minnesota USA

Department of Medicine Cumming School of Medicine University of Calgary Calgary Alberta Canada

Department of Medicine Geffen School of Medicine University of California Los Angeles Los Angeles California USA

Department of Nephrology 1st Faculty of Medicine and General University Hospital Charles University Prague Czech Republic

Department of Nephrology and Mineral Metabolism Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran Mexico City Mexico

Department of Nephrology and Renal Transplantation CIC INSERM 1402 Centre Hospitalier Universitaire University Hospital Poitiers Poitiers France

Department of Nephrology Juntendo University Tokyo Japan

Department of Nephrology Radboud University Medical Center Nijmegen The Netherlands

Department of Pediatric Subspecialties Division of Nephrology and Dialysis Ospedale Pediatrico Bambino Gesù Rome Italy

Division of Experimental Medicine and Immunotherapeutics School of Clinical Medicine University of Cambridge Cambridge UK

Division of Nephrology and Hypertension Los Angeles Biomedical Research Institute Los Angeles California USA

Division of Nephrology and Hypertension Mayo Clinic Rochester Minnesota USA

Division of Nephrology Department of Internal Medicine University of Groningen Groningen The Netherlands

Division of Nephrology Department of Medicine Columbia University Medical Center New York New York USA

Division of Nephrology Department of Medicine University of Hong Kong Hong Kong China

Division of Nephrology Mass General Brigham Salem Hospital Salem Massachusetts USA

Division of Nephrology University Hospital Rheinisch Westfälische Technische Hochschule Aachen Aachen Germany

Divsion of Nephrology Department of Medicine University of Toronto Toronto Ontario Canada

KDIGO Brussels Belgium

MAGIC Evidence Ecosystem Foundation Hamilton Ontario Canada; Department of Health Research Methods Evidence and Impact McMaster University Hamilton Ontario Canada

Molecular Otolaryngology and Renal Research Laboratories University of Iowa Iowa City Iowa USA

Nanjing University School of Medicine Nanjing China

Ohio Kidney Associates Columbus Ohio USA

Renal and Transplant Centre Imperial College London London UK

Sorbonne University and Institut National de la Santé et de la Recherche Médicale Unité Mixte de Recherche S1155 Paris France; Le Mans Hospital Le Mans France

The George Institute for Global Health New Delhi India; School of Public Health Imperial College London London UK; Prasanna School of Public Health Manipal Academy of Higher Education Manipal India

The Kidney and Transplant Practice Mount Elizabeth Novena Hospital Singapore

University of North Carolina Kidney Center at Chapel Hill Chapel Hill North Carolina USA

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