Human cells are subjected to continuous challenges by different genotoxic stress attacks. DNA damage leads to erroneous mutations, which can alter the function of oncogenes or tumor suppressors, resulting in cancer development. To circumvent this, cells activate the DNA damage response (DDR), which mainly involves cell cycle regulation and DNA repair processes. The tumor suppressor p53 plays a pivotal role in the DDR by halting the cell cycle and facilitating the DNA repair processes. Various pathways and factors participating in the detection and repair of DNA have been described, including scores of RNA-binding proteins (RBPs) and RNAs. It has become increasingly clear that p53's role is multitasking, and p53 mRNA regulation plays a prominent part in the DDR. This review is aimed at covering the p53 RNA metabolism linked to the DDR and highlights the recent findings.

Department of Medical Biosciences Umeå University 901 87 Umeå Sweden

Inserm UMRS1131 Institut de Genetique Moleculaire Universite Paris 7 Hopital St Louis F 75010 Paris France

International Centre for Cancer Vaccine Science University of Gdansk 80 822 Gdansk Poland

RECAMO Masaryk Memorial Cancer Institute Zluty Kopec 7 656 53 Brno Czech Republic

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The p53 endoplasmic reticulum stress-response pathway evolved in humans but not in mice via PERK-regulated p53 mRNA structures