Nanotechnology is gaining significant attention, with numerous biomedical applications. Silver in wound dressings, copper oxide and silver in antibacterial preparations, and zinc oxide nanoparticles as a food and cosmetic ingredient are common examples. However, adverse effects of nanoparticles in humans and the environment from extended exposure at varied concentrations have yet to be established. One of the drawbacks of employing nanoparticles is their tendency to cause oxidative stress, a significant public health concern with life-threatening consequences. Cardiovascular, renal, and respiratory problems and diabetes are among the oxidative stress-related disorders. In this context, phytoantioxidant functionalized nanoparticles could be a novel and effective alternative. In addition to performing their intended function, they can protect against oxidative damage. This review was designed by searching through various websites, books, and articles found in PubMed, Science Direct, and Google Scholar. To begin with, oxidative stress, its related diseases, and the mechanistic basis of oxidative damage caused by nanoparticles are discussed. One of the main mechanisms of action of nanoparticles was unearthed to be oxidative stress, which limits their use in humans. Secondly, the role of phytoantioxidant functionalized nanoparticles in oxidative damage prevention is critically discussed. The parameters for the characterization of nanoparticles were also discussed. The majority of silver, gold, iron, zinc oxide, and copper nanoparticles produced utilizing various plant extracts were active free radical scavengers. This potential is linked to several surface fabricated phytoconstituents, such as flavonoids and phenols. These phytoantioxidant functionalized nanoparticles could be a better alternative to nanoparticles prepared by other existing approaches.

Biomedical Research Center University Hospital in Hradec Kralove Sokolska 581 Hradec Kralove 50005 Czech Republic

Center for Basic and Applied Science Faculty of Informatics and Management University of Hradec Kralove 50003 Hradec Kralove Czech Republic

Department of Allied Sciences University of Patanjali Haridwar 249405 India

Department of Chemistry Faculty of Science University of Hradec Kralove Hradec Kralove 50003 Czech Republic

Department of Physics Career Point University Hamirpur 177001 India

Malaysia Japan International Institute of Technology Universiti Teknologi Malaysia Jalan Sultan Yahya Petra Kuala Lumpur 54100 Malaysia

Patanjali Herbal Research Department Patanjali Research Institute Haridwar 249405 India

School of Bioengineering and Food Technology Shoolini University of Biotechnology and Management Sciences Solan 173229 India

School of Biological and Environmental Sciences Shoolini University of Biotechnology and Management Sciences Solan 173229 India

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