Carbon dots for virus detection and therapy
Language English Country Austria Media electronic
Document type Journal Article, Research Support, Non-U.S. Gov't, Review
Grant support
CZ.02.1.01/0.0/0.0/16_019/0000754
european regional development fund
IGA-PrF-2021-028
univerzita palackého v olomouci
PubMed
34822008
PubMed Central
PMC8613466
DOI
10.1007/s00604-021-05076-6
PII: 10.1007/s00604-021-05076-6
Knihovny.cz E-resources
- Keywords
- Antiviral, Biosensors, COVID-19, Carbon dots, Coronavirus, Functionalization of carbon dots, Virus detection,
- MeSH
- Antiviral Agents pharmacology MeSH
- Biocompatible Materials MeSH
- Biosensing Techniques MeSH
- Molecular Targeted Therapy MeSH
- COVID-19 diagnosis therapy MeSH
- Electrochemistry MeSH
- COVID-19 Drug Treatment * MeSH
- Phototherapy MeSH
- Quantum Dots * MeSH
- Humans MeSH
- Nanostructures MeSH
- Polymers MeSH
- SARS-CoV-2 MeSH
- COVID-19 Testing methods MeSH
- Carbon chemistry MeSH
- Virus Diseases MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
- Names of Substances
- Antiviral Agents MeSH
- Biocompatible Materials MeSH
- Polymers MeSH
- Carbon MeSH
Recent experience with the COVID-19 pandemic should be a lesson learnt with respect to the effort we have to invest in the development of new strategies for the treatment of viral diseases, along with their cheap, easy, sensitive, and selective detection. Since we live in a globalized world where just hours can play a crucial role in the spread of a virus, its detection must be as quick as possible. Thanks to their chemical stability, photostability, and superior biocompatibility, carbon dots are a kind of nanomaterial showing great potential in both the detection of various virus strains and a broad-spectrum antiviral therapy. The biosensing and antiviral properties of carbon dots can be tuned by the selection of synthesis precursors as well as by easy post-synthetic functionalization. In this review, we will first summarize current options of virus detection utilizing carbon dots by either electrochemical or optical biosensing approaches. Secondly, we will cover and share the up-to-date knowledge of carbon dots' antiviral properties, which showed promising activity against various types of viruses including SARS-CoV-2. The mechanisms of their antiviral actions will be further adressed as well. Finally, we will discuss the advantages and distadvantages of the use of carbon dots in the tangled battle against viral infections in order to provide valuable informations for further research and development of new virus biosensors and antiviral therapeutics.
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