Triacylglycerols containing branched palmitic acid ester of hydroxystearic acid (PAHSA) are present in the breast milk and hydrolyzed by carboxyl ester lipase
Language English Country Great Britain, England Media print-electronic
Document type Journal Article
PubMed
35486985
DOI
10.1016/j.foodchem.2022.132983
PII: S0308-8146(22)00945-1
Knihovny.cz E-resources
- Keywords
- Colostrum, Elective caesarean section, Human breast milk, Lipidomics, PAHSA, Preterm birth,
- MeSH
- Cesarean Section MeSH
- Esters metabolism MeSH
- Infant MeSH
- Colostrum metabolism MeSH
- Palmitic Acid metabolism MeSH
- Lactation MeSH
- Humans MeSH
- Lipase metabolism MeSH
- Milk, Human * metabolism MeSH
- Infant, Newborn MeSH
- Premature Birth * metabolism MeSH
- Case-Control Studies MeSH
- Pregnancy MeSH
- Triglycerides metabolism MeSH
- Check Tag
- Infant MeSH
- Humans MeSH
- Infant, Newborn MeSH
- Pregnancy MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- CEL protein, human MeSH Browser
- Esters MeSH
- Palmitic Acid MeSH
- Lipase MeSH
- Triglycerides MeSH
Breast milk is a complex mixture containing underexplored bioactive lipids. We performed an observational case-control study to compare the impact of delivery mode: caesarean section (CS) and vaginal birth (VB); and term (preterm and term delivery) on the levels of lipokines in human milk at different stages of lactation. Metabolomic analysis of the milk identified triacylglycerol estolides as a metabolic reservoir of the anti-inflammatory lipid mediator 5-palmitic acid ester of hydroxystearic acid (5-PAHSA). We found that triacylglycerol estolides were substrates of carboxyl ester lipase and 5-PAHSA-containing lipids were the least preferred substrates among tested triacylglycerol estolide isomers. This explained exceptionally high colostrum levels of 5-PAHSA in the VB group. CS and preterm birth negatively affected colostrum lipidome, including 5-PAHSA levels, but the lipidomic profiles normalized in mature milk. Mothers delivering term babies vaginally produce colostrum rich in 5-PAHSA, which could contribute to the prevention of intestinal inflammation in newborns.
Institut des Biomolecules Max Mousseron University Montpellier CNRS ENSCM Montpellier France
Institute for the Care of Mother and Child Prague Czech Republic
Institute of Physiology of the Czech Academy of Sciences Videnska 1083 14220 Praha 4 Czech Republic
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