BJOG, ISSN 1470-0328 vol. 112, suppl. 1, March 2005
121 s. : il., tab. ; 28 cm
- MeSH
- Pregnancy Complications MeSH
- Obstetrics MeSH
- Obstetric Labor, Premature drug therapy epidemiology prevention & control MeSH
- Fetal Membranes, Premature Rupture diagnosis drug therapy MeSH
- Publication type
- Congress MeSH
- Collected Work MeSH
- Conspectus
- Gynekologie. Porodnictví
- NML Fields
- gynekologie a porodnictví
- gynekologie a porodnictví
Clinical obstetrics and gynecology, ISSN 0009-9201 vol. 47, no. 4, December 2004
viii, 753-981 s. : il., tab., grafy ; 26 cm
- MeSH
- Reproductive Techniques, Assisted MeSH
- Cerclage, Cervical MeSH
- Pregnancy Complications MeSH
- Obesity complications therapy MeSH
- Premature Birth prevention & control MeSH
- Pregnancy MeSH
- Check Tag
- Pregnancy MeSH
- Conspectus
- Gynekologie. Porodnictví
- NML Fields
- gynekologie a porodnictví
- gynekologie a porodnictví
- vnitřní lékařství
BJOG, ISSN 0140-7686 vol. 113, suppl. 3, December 2006
138 s. : il., tab. ; 28 cm
- MeSH
- Diagnostic Imaging MeSH
- Obstetric Labor Complications MeSH
- Infant, Premature MeSH
- Premature Birth MeSH
- Publication type
- Congress MeSH
- Collected Work MeSH
- MeSH
- Receptors, Adrenergic, beta-2 genetics MeSH
- Interleukins genetics MeSH
- Humans MeSH
- Matrix Metalloproteinases genetics MeSH
- Polymorphism, Genetic MeSH
- Premature Birth genetics immunology MeSH
- Pregnancy MeSH
- Toll-Like Receptors genetics MeSH
- Tumor Necrosis Factors physiology genetics MeSH
- Vascular Endothelial Growth Factors genetics MeSH
- Check Tag
- Humans MeSH
- Pregnancy MeSH
- Female MeSH
American journal of obstetrics and gynecology, ISSN 0002-9378 vol. 180, no. 1, January 1999, part 3, suppl.
4A, S207-S273 s. : tab., il. ; 30 cm
- MeSH
- Estriol MeSH
- Corticotropin-Releasing Hormone MeSH
- Maternal-Fetal Exchange MeSH
- Pregnancy physiopathology MeSH
- Check Tag
- Pregnancy physiopathology MeSH
- Conspectus
- Lékařské vědy. Lékařství
- NML Fields
- gynekologie a porodnictví
- endokrinologie
BACKGROUND: Preterm birth, low birth weight, and infant catch-up growth seem associated with an increased risk of respiratory diseases in later life, but individual studies showed conflicting results. OBJECTIVES: We performed an individual participant data meta-analysis for 147,252 children of 31 birth cohort studies to determine the associations of birth and infant growth characteristics with the risks of preschool wheezing (1-4 years) and school-age asthma (5-10 years). METHODS: First, we performed an adjusted 1-stage random-effect meta-analysis to assess the combined associations of gestational age, birth weight, and infant weight gain with childhood asthma. Second, we performed an adjusted 2-stage random-effect meta-analysis to assess the associations of preterm birth (gestational age <37 weeks) and low birth weight (<2500 g) with childhood asthma outcomes. RESULTS: Younger gestational age at birth and higher infant weight gain were independently associated with higher risks of preschool wheezing and school-age asthma (P < .05). The inverse associations of birth weight with childhood asthma were explained by gestational age at birth. Compared with term-born children with normal infant weight gain, we observed the highest risks of school-age asthma in children born preterm with high infant weight gain (odds ratio [OR], 4.47; 95% CI, 2.58-7.76). Preterm birth was positively associated with an increased risk of preschool wheezing (pooled odds ratio [pOR], 1.34; 95% CI, 1.25-1.43) and school-age asthma (pOR, 1.40; 95% CI, 1.18-1.67) independent of birth weight. Weaker effect estimates were observed for the associations of low birth weight adjusted for gestational age at birth with preschool wheezing (pOR, 1.10; 95% CI, 1.00-1.21) and school-age asthma (pOR, 1.13; 95% CI, 1.01-1.27). CONCLUSION: Younger gestational age at birth and higher infant weight gain were associated with childhood asthma outcomes. The associations of lower birth weight with childhood asthma were largely explained by gestational age at birth.
- MeSH
- Asthma * epidemiology pathology physiopathology MeSH
- Gestational Age * MeSH
- Weight Gain * MeSH
- Infant MeSH
- Humans MeSH
- Infant, Newborn MeSH
- Birth Weight * MeSH
- Premature Birth * epidemiology pathology physiopathology MeSH
- Risk Factors MeSH
- Check Tag
- Infant MeSH
- Humans MeSH
- Male MeSH
- Infant, Newborn MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Meta-Analysis MeSH
- Research Support, Non-U.S. Gov't MeSH
- Geographicals
- Europe MeSH
Background Patent ductus arteriosus (PDA) is common in very premature infants. Pharmacological closure of PDA with indomethacin, a prostaglandin inhibitor, has remained the mainstay of treatment in premature infants over the last three decades. Intravenous ibuprofen was recently shown to be as effective and to have fewer adverse reaction in preterm infants. If equally effective, then oral ibuprofen for PDA closure would have several important advantages over the intravenous route. This study was designed to assess the efficacy and safety of oral ibuprofen and intravenous ibuprofen for the early pharmacological treatment of PDA in LBW preterm infants with respiratory distress syndrome. Methods A randomized, single-blinded, controlled study was performed on premature neonates at the neonatal care unit of the University Hospital for Obstetrics and Gynecology”Koco Gliozheni”, Tirana, Albania, from January 2010 to December 2012. The study enrolled 68 preterm infants with gestational age between 28-32 weeks, birth weight ≤ 2000 g, postnatal age 48-96 h, and had echocardiographically confirmed significant PDA. The preterm infants received either intravenous or oral ibuprofen randomly as an initial dose of 10 mg/kg, followed by 5 mg/kg at 24 and 48 h. After the first dose of treatment in both groups, echocardiographic evaluation was performed, to determine the need for a second or third dose. The rate of ductal closure, adverse effects, complications, and the patient’s clinical course were recorded. Results All patients were born after 28 until 32 weeks’ gestation. 36 patients were treated with oral ibuprofen and 32 with intravenous ibuprofen in this period. After the first course of the treatment, the PDA closed in 30 (83.3%) of the patients assigned to the oral ibuprofen group versus 23 (71.8%) of those enrolled in the intravenous ibuprofen group (p = 0.355). There was no difference between treatment groups in demographics or baseline renal function. In the evaluation of renal tolerance, none of the patients had oliguria. There were no significant differences with respect to complications during the stay. Conclusions In low birth weight infants, the rate of early ductal closure with oral ibuprofen is at least as good as with the intravenous route. Oral ibuprofen is associated with fewer adverse effects
- MeSH
- Administration, Oral * MeSH
- Echocardiography, Doppler, Color MeSH
- Blood Urea Nitrogen MeSH
- Gestational Age MeSH
- Ibuprofen * administration & dosage adverse effects MeSH
- Administration, Intravenous * statistics & numerical data MeSH
- Creatinine blood MeSH
- Humans MeSH
- Infant, Premature, Diseases drug therapy MeSH
- Infant, Premature MeSH
- Infant, Low Birth Weight * MeSH
- Infant, Newborn MeSH
- Oliguria chemically induced MeSH
- Ductus Arteriosus, Patent * drug therapy MeSH
- Birth Weight MeSH
- Prospective Studies MeSH
- Statistics as Topic MeSH
- Treatment Outcome MeSH
- Check Tag
- Humans MeSH
- Male MeSH
- Infant, Newborn MeSH
- Female MeSH
Clinical obstetrics and gynecology
S.537-694 : obr.,tab.,přeruš.bibl.
OBJECTIVE: To evaluate the amount of macronutrients in aggregate of human milk samples after preterm delivery during the first 2 months of lactation. METHODS: Analysis of the donated single milk samples, gained by complete emptying of the whole breast at the same daytime between 24+0 and 35+6 gestational age (GA), was designed as prospective observational cohort trial. Two milk samples were analysed every postnatal week up to the discharge from the hospital, week 9 or loss of lactation. 24-Hour milk collection was not done. Analysis was performed using the MIRIS Human Milk Analyser (MIRIS AB, Uppsala, Sweden). RESULTS: A set of 1917 human milk samples donated by 225 mothers after preterm labour was analysed. Group A (24-30 GA) contains 969 milk samples; group B (31-35 GA) contains 948 milk samples. No difference in milk composition between the groups was identified. Median of true protein content decreased from 1.6 g/dL in group A and 1.5 g/dL in group B in the first week of life, to 1.1 g/dL in both groups at the end of week 3, and then remained stable up to week 9. Content of carbohydrates and fat was stable during the whole observation, with interindividual differences. CONCLUSION: Human milk does not differ as a function of degree of prematurity. Protein content of preterm human milk is low and decreases during the first 3 weeks of lactation. Recommended daily protein intake cannot be achieved with routine fortification in majority of milk samples.
- MeSH
- Gestational Age * MeSH
- Infant MeSH
- Breast Feeding MeSH
- Humans MeSH
- Milk, Human chemistry MeSH
- Milk Proteins analysis MeSH
- Infant, Newborn MeSH
- Premature Birth pathology MeSH
- Prospective Studies MeSH
- Nutrients analysis MeSH
- Check Tag
- Infant MeSH
- Humans MeSH
- Infant, Newborn MeSH
- Publication type
- Journal Article MeSH
- Observational Study MeSH
Objective: To profile maternal plasma metabolome in spontaneous preterm birth. Method: In this retrospective case-control study, we have examined plasma of patient with preterm birth (between 22 and 36 weeks of pregnancy (n = 57)), with threatened preterm labor (between 23 and 36 weeks of pregnancy (n = 49)), and with term delivery (n = 25). Plasma samples were analysed using liquid chromatography quadrupole time-of-flight mass spectrometry (LC-Q-TOF-MS) in positive and negative polarity modes. Results: We found 168 differentially expressed metabolites that were significantly distinct between study groups. We determined 51 metabolites using publicly available databases that could be subdivided into one of the five groups: amino acids, fatty acids, lipids, hormones, and bile acids. PLS-DA models, verified by SVM classification accuracy, differentiated preterm birth and term delivery groups. Conclusions: Maternal plasma metabolites are different between term and preterm parturitions. Part of them may be related with preterm labor, while others may be affected by gestational age or the beginning of labor. Metabolite profile can classify preterm or term delivery groups raising the potential of metabolome as a biomarker to identify high-risk pregnancies. Metabolomic studies are also a tool to detect individual compounds that may be further tested in targeted researches.
- MeSH
- Adult MeSH
- Gestational Age MeSH
- Humans MeSH
- Young Adult MeSH
- Multivariate Analysis MeSH
- Obstetric Labor, Premature blood MeSH
- Premature Birth blood MeSH
- Retrospective Studies MeSH
- Case-Control Studies MeSH
- Pregnancy MeSH
- Check Tag
- Adult MeSH
- Humans MeSH
- Young Adult MeSH
- Pregnancy MeSH
- Female MeSH
- Publication type
- Journal Article MeSH