Diagnosis of Aspergillosis in Horses
Status PubMed-not-MEDLINE Jazyk angličtina Země Švýcarsko Médium electronic
Typ dokumentu časopisecké články
Grantová podpora
21-17044S
Grant Agency of the Czech Republic
109/2019/FVL
Internal Grant Agency of the University of Veterinary Sciences Brno
PubMed
36836276
PubMed Central
PMC9966232
DOI
10.3390/jof9020161
PII: jof9020161
Knihovny.cz E-zdroje
- Klíčová slova
- (1,3)-β-D-glucan, bronchoalveolar lavage fluid, equine aspergillosis, equine asthma, equine herpes virus-5, fungal secondary metabolites, galactomannan, guttural pouch, invasive pulmonary aspergillosis, serum, tracheal wash,
- Publikační typ
- časopisecké články MeSH
Invasive pulmonary aspergillosis (IPA) may be a rare cause of granulomatous pneumonia in horses. The mortality of IPA is almost 100%; direct diagnostic tools in horses are needed. Bronchoalveolar lavage fluid (BALF) and serum samples were collected from 18 horses, including individuals suffering from IPA (n = 1), equine asthma (EA, n = 12), and 5 healthy controls. Serum samples were collected from another 6 healthy controls. Samples of BALF (n = 18) were analyzed for Aspergillus spp. DNA, fungal galactomannan (GM), ferricrocin (Fc), triacetylfusarinin C (TafC), and gliotoxin (Gtx). Analysis of 24 serum samples for (1,3)-β-D-glucan (BDG) and GM was performed. Median serum BDG levels were 131 pg/mL in controls and 1142 pg/mL in IPA. Similar trends were observed in BALF samples for GM (Area under the Curve (AUC) = 0.941) and DNA (AUC = 0.941). The fungal secondary metabolite Gtx was detected in IPA BALF and lung tissue samples (86 ng/mL and 2.17 ng/mg, AUC = 1).
California Institute for Medical Research San Jose CA 95128 USA
Department of Molecular Biology Public Health Institute in Ostrava 702 00 Ostrava Czech Republic
Equine Clinic University of Veterinary Sciences 612 42 Brno Czech Republic
Institute of Microbiology of the Czech Academy of Sciences 142 20 Prague Czech Republic
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