ABCA3 and LZTFL1 Polymorphisms and Risk of COVID-19 in the Czech Population
Jazyk angličtina Země Česko Médium print
Typ dokumentu časopisecké články
PubMed
37795896
PubMed Central
PMC10634566
DOI
10.33549/physiolres.935108
PII: 935108
Knihovny.cz E-zdroje
- MeSH
- ABC transportéry genetika MeSH
- COVID-19 * diagnóza epidemiologie genetika MeSH
- genotyp MeSH
- lidé MeSH
- polymorfismus genetický MeSH
- SARS-CoV-2 MeSH
- transkripční faktory genetika MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- Geografické názvy
- Česká republika MeSH
- Názvy látek
- ABC transportéry MeSH
- ABCA3 protein, human MeSH Prohlížeč
- LZTFL1 protein, human MeSH Prohlížeč
- transkripční faktory MeSH
SARS-CoV-2 infection, which causes the respiratory disease COVID-19, has spread rapidly from Wuhan, China, since 2019, causing nearly 7 million deaths worldwide in three years. In addition to clinical risk factors such as diabetes, hypertension, and obesity, genetic variability is an important predictor of disease severity and susceptibility. We analyzed common polymorphisms within the LZTFL1 (rs11385942) and ABCA3 (rs13332514) genes in 519 SARS-CoV-2-positive subjects (164 asymptomatic, 246 symptomatic, and 109 hospitalized COVID-19 survivors) and a population-based control group (N?=?2,592; COVID-19 status unknown). Rare ABCA3 AA homozygotes (but not A allele carriers) may be at a significantly increased risk of SARS-CoV-2 infection [P?=?0.003; OR (95 % CI); 3.66 (1.47-9.15)]. We also observed a borderline significant difference in the genotype distribution of the LZTFL1 rs11385942 polymorphism (P?=?0.04) between the population sample and SARS-CoV-2-positive subjects. In agreement with previous studies, a nonsignificantly higher frequency of minor allele carriers was detected among hospitalized COVID-19 subjects. We conclude that a common polymorphism in the ABCA3 gene may be a significant predictor of susceptibility to SARS-CoV-2 infection.
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