SUMMARY: The SBILib Python library provides an integrated platform for the analysis of macromolecular structures and interactions. It combines simple 3D file parsing and workup methods with more advanced analytical tools. SBILib includes modules for macromolecular interactions, loops, super-secondary structures, and biological sequences, as well as wrappers for external tools with which to integrate their results and facilitate the comparative analysis of protein structures and their complexes. The library can handle macromolecular complexes formed by proteins and/or nucleic acid molecules (i.e. DNA and RNA). It is uniquely capable of parsing and calculating protein super-secondary structure and loop geometry. We have compiled a list of example scenarios which SBILib may be applied to and provided access to these within the library. AVAILABILITY AND IMPLEMENTATION: SBILib is made available on Github at https://github.com/structuralbioinformatics/SBILib.

Department of Medical Genetics Centre for Molecular Medicine and Therapeutics BC Children's Hospital Research Institute University of British Columbia Vancouver BC V5Z 4H4 Canada

Department of Medicine and Life Sciences SBI GRIB Universitat Pompeu Fabra 08003 Barcelona Catalonia Spain

Institute of Biological Environmental and Rural Science Aberystwyth University Aberystwyth SY23 3DA United Kingdom

International Clinical Research Center St Anne's University Hospital Brno 656 916 Brno Czech Republic

Loschmidt Laboratories Department of Experimental Biology and RECETOX Faculty of Science Masaryk University 625 00 Brno Czech Republic

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