Digital weight loss interventions present a viable and cost-effective alternative to traditional therapy. However, further evidence is needed to establish the equal effectiveness of both approaches. This randomized controlled non-inferiority trial aimed to compare the effects of an intensive in-person weight loss intervention program with Vitadio digital therapy. One hundred patients with obesity and diagnosed with type 2 diabetes, prediabetes, or insulin resistance were enrolled and randomly assigned to one of the two treatment groups. Over a 6-month period, the control group received five in-person consultations with a physician who specialized in obesity treatment, a dietitian and/or a nutrition nurse, while the intervention group followed the digital program based on a multimodal therapeutic approach. The extent of weight loss was assessed and compared between the groups. Additionally, changes in body composition and metabolic parameters for the digital intervention group were analyzed. The study results demonstrated comparable effectiveness of both treatments for weight reduction. The positive effects of Vitadio were further evidenced by favorable changes in body composition and lipid metabolism and improved glycemic control in the intervention group. These findings suggest that Vitadio is an effective tool for assisting patients with managing obesity and preventing diabetes progression.

1st Faculty of Medicine Charles University Prague Kateřinská 32 121 08 Prague Czech Republic

Department of Exercise Medicine and Cardiovascular Rehabilitation University Hospital Olomouc 1 P Pavlova 6 779 00 Olomouc Czech Republic

Department of Public Health Masaryk University Kamenice 5 625 00 Brno Czech Republic

Faculty of Medicine Palacký University Olomouc Hněvotínská 3 775 15 Olomouc Czech Republic

Vitadio s r o Římská 678 26 120 00 Prague Czech Republic

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