Biliary drainage is then one of the necessary procedures to help patients suffering from icterus to reduce serum bilirubin levels and relieve symptoms. The aim of this study was identifying risk factors for survival in patients with cholangiocarcinoma (CCA) treated with percutaneous transhepatic biliary drainage (PTBD) and to develop a simple scoring system predicting survival from PTBD insertion. This single-centre retrospective study included 175 consecutive patients undergoing PTBD for extrahepatic CCA (perihilar and distal). Prognostic factors affecting survival of patients with CCA treated with PTBD were analysed. A multivariate analysis showed that mass forming tumor with mass larger than 5 cm and presence of metastasis at the time of PTBD served as a negative prognostic factor (p = 0.002), better survival was associated with lower preprocedural bilirubin and lower CRP (p = 0.003). Multivariate analysis identified two significant risk factors for 3-month mortality: mass-forming tumors and bilirubin levels exceeding 185 µmol/L. A simple scoring system was developed to predict 3-month mortality after PTBD in patients with advanced CCA, demonstrating 86.3% negative predictive value and 43.2% positive predictive value.

Department of Hematology Oncology and Internal Medicine University Hospital Brno 625 00 Brno Czechia

Department of Radiology and Nuclear Medicine Faculty of Medicine University Hospital Brno Masaryk University Brno 625 00 Czech Republic

Department of Radiology and Nuclear Medicine University Hospital Brno Brno 625 00 Czechia

Masaryk Memorial Cancer Institute Brno 60200 Czechia Czechia

Medical Faculty Masaryk University Brno 625 00 Czechia

University Hospital Ostrava Ostrava 708 00 Czechia

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