Pre-B-Cell Leukemia Transcription Factor 1 [pre-B-buněčný leukemický transkripční faktor 1]

topical
2
Terms

homeodoménový protein PBX1
homeoprotein PBX1

 

PBX1 Homeobox Protein
Pre-B-Cell Leukemia Homeobox 1 Protein

Persistent link   https://www.medvik.cz/link/D000075062
Definition

A TALE-type homeodomain protein and transcription factor that binds the DNA sequence 5'-ATCAATCAA-3'. It forms a heterodimer with MEIS1 TRANSCRIPTION FACTOR and functions as a transcriptional activator of HOMEOBOX PROTEIN NKX-2.5 and ELONGIN A, and as a transcriptional repressor of CDKN2B PROTEIN, in the regulation of developmental and morphogenetic processes such as spleen and limb development. Chromosome translocations involving the PBX1 and TCF3 genes occur in cases of pre-B-cell ACUTE LYMPHOID LEUKEMIA.

DUI
D000075062 MeSH Browser
CUI
M000629051
Previous indexing
DNA-Binding Proteins (1993-2017); Proto-Oncogene Proteins (1993-2017)
History note
2018
Public note
2018

Allowable subheadings

AD
administration & dosage
AE
adverse effects
AG
agonists
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry 1
CL
classification
DF
deficiency
DE
drug effects
EC
economics
GE
genetics 1
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism 1
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine

D Chemicals and Drugs
D12 Amino Acids, Peptides, and Proteins 16
D12.776 Proteins 2 577
D12.776.260 DNA-Binding Proteins 556
D12.776.260.400 Homeodomain Proteins 122
D12.776.260.400.124 Antennapedia Homeodomain Protein 1
D12.776.260.400.140 CDX2 Transcription Factor 3
D12.776.260.400.155 Fushi Tarazu Transcription Factors
D12.776.260.400.186 Goosecoid Protein 2
D12.776.260.400.218 Hepatocyte Nuclear Factor 1 1
D12.776.260.400.226 Homeobox A10 Proteins
D12.776.260.400.228 Homeobox Protein PITX2
D12.776.260.400.230 Homeobox Protein Nkx-2.2
D12.776.260.400.234 Homeobox Protein Nkx-2.5 1
D12.776.260.400.242 Homeobox Protein SIX3
D12.776.260.400.249 MADS Domain Proteins 3
D12.776.260.400.436 MSX1 Transcription Factor 8
D12.776.260.400.483 Myeloid Ecotropic Viral Integration Site 1 Protein 1
D12.776.260.400.530 Nanog Homeobox Protein 3
D12.776.260.400.624 Onecut Transcription Factors
D12.776.260.400.718 Otx Transcription Factors 4
D12.776.260.400.812 PAX7 Transcription Factor 2
D12.776.260.400.836 Pre-B-Cell Leukemia Transcription Factor 1 2
D12.776.260.400.848 Prospero-Related Homeobox 1 Protein
D12.776.260.400.859 Short Stature Homeobox Protein 8
D12.776.260.400.871 Thyroid Nuclear Factor 1
D12.776.260.400.883 Zinc Finger E-box Binding Homeobox 2 3
D12.776.260.400.906 Zinc Finger E-box-Binding Homeobox 1 6
D12.776.624 Neoplasm Proteins 412
D12.776.624.664 Oncogene Proteins 125
D12.776.624.664.700 Proto-Oncogene Proteins 263
D12.776.624.664.700.013 Axl Receptor Tyrosine Kinase
D12.776.624.664.700.025 Bcl-2-Like Protein 11 5
D12.776.624.664.700.037 c-Mer Tyrosine Kinase 2
D12.776.624.664.700.049 Chemokine CXCL1 7
D12.776.624.664.700.100 Cyclin D1 86
D12.776.624.664.700.110 Fibroblast Growth Factor 4 2
D12.776.624.664.700.112 Fibroblast Growth Factor 6
D12.776.624.664.700.114 fms-Like Tyrosine Kinase 3 49
D12.776.624.664.700.117 Janus Kinase 2 79
D12.776.624.664.700.119 KRIT1 Protein
D12.776.624.664.700.120 Kruppel-Like Factor 6 1
D12.776.624.664.700.123 Lipocalin-2 21
D12.776.624.664.700.128 Lymphocyte Specific Protein Tyrosine Kinase p56(lck) 10
D12.776.624.664.700.129 MDS1 and EVI1 Complex Locus Protein 2
D12.776.624.664.700.130 MutS Homolog 2 Protein 17
D12.776.624.664.700.148 Myeloid-Lymphoid Leukemia Protein 39
D12.776.624.664.700.158 N-Myc Proto-Oncogene Protein 9
D12.776.624.664.700.163 Pre-B-Cell Leukemia Transcription Factor 1 2
D12.776.624.664.700.165 B-Cell Lymphoma 3 Protein
D12.776.624.664.700.166 Proto-Oncogene Mas 2
D12.776.624.664.700.167 Proto-Oncogene Proteins c-abl 7
D12.776.624.664.700.168 Proto-Oncogene Proteins c-akt 117
D12.776.624.664.700.169 Proto-Oncogene Proteins c-bcl-2 147
D12.776.624.664.700.170 Proto-Oncogene Proteins c-bcl-6 3
D12.776.624.664.700.171 Proto-Oncogene Proteins c-bcr 19
D12.776.624.664.700.172 Proto-Oncogene Proteins c-cbl 5
D12.776.624.664.700.174 Proto-Oncogene Proteins c-crk 1
D12.776.624.664.700.175 Proto-Oncogene Proteins c-ets 19
D12.776.624.664.700.177 Proto-Oncogene Proteins c-fes
D12.776.624.664.700.179 Proto-Oncogene Proteins c-fos 61
D12.776.624.664.700.180 Proto-Oncogene Proteins c-fyn 4
D12.776.624.664.700.181 Proto-Oncogene Proteins c-hck 1
D12.776.624.664.700.182 Proto-Oncogene Proteins c-jun 17
D12.776.624.664.700.183 Proto-Oncogene Proteins c-kit 77
D12.776.624.664.700.184 Proto-Oncogene Proteins c-maf 1
D12.776.624.664.700.185 Proto-Oncogene Proteins c-mdm2 65
D12.776.624.664.700.186 Proto-Oncogene Proteins c-met 30
D12.776.624.664.700.187 Proto-Oncogene Proteins c-mos 2
D12.776.624.664.700.188 Proto-Oncogene Proteins c-myb 30
D12.776.624.664.700.189 Proto-Oncogene Proteins c-myc 66
D12.776.624.664.700.191 Proto-Oncogene Proteins c-pim-1 1
D12.776.624.664.700.192 Proto-Oncogene Proteins c-rel 2
D12.776.624.664.700.194 Proto-Oncogene Proteins c-ret 42
D12.776.624.664.700.195 Proto-Oncogene Proteins c-sis 3
D12.776.624.664.700.198 Proto-Oncogene Proteins c-vav 4
D12.776.624.664.700.199 Proto-Oncogene Proteins c-yes 1
D12.776.624.664.700.200 Proto-Oncogene Proteins p21(ras) 71
D12.776.624.664.700.202 Proto-Oncogene Proteins pp60(c-src) 7
D12.776.624.664.700.204 raf Kinases 70
D12.776.624.664.700.642 Receptor, ErbB-2 585
D12.776.624.664.700.790 Receptor, ErbB-3 9
D12.776.624.664.700.791 Receptor, ErbB-4
D12.776.624.664.700.792 Receptor, Fibroblast Growth Factor, Type 3 27
D12.776.624.664.700.800 Receptor, Macrophage Colony-Stimulating Factor 1
D12.776.624.664.700.815 Receptor, Notch4
D12.776.624.664.700.830 Receptors, Thyroid Hormone 40
D12.776.624.664.700.913 RNA-Binding Protein EWS 15
D12.776.624.664.700.915 RNA-Binding Protein FUS 6
D12.776.624.664.700.936 RUNX1 Translocation Partner 1 Protein
D12.776.624.664.700.957 Stathmin 4
D12.776.624.664.700.960 T-Cell Acute Lymphocytic Leukemia Protein 1
D12.776.624.664.700.962 Wnt-5a Protein 5
D12.776.624.664.700.967 Wnt1 Protein 4
D12.776.624.664.700.978 Wnt2 Protein
D12.776.624.664.700.989 Zinc Finger Protein GLI1 7
D12.776.930 Transcription Factors 727
D12.776.930.100 Adenovirus E1A Proteins 5
D12.776.930.110 Adenovirus E1B Proteins 3
D12.776.930.120 Antennapedia Homeodomain Protein 1
D12.776.930.123 AIRE Protein 2
D12.776.930.125 Basic Helix-Loop-Helix Transcription Factors 61
D12.776.930.127 Basic-Leucine Zipper Transcription Factors 18
D12.776.930.130 beta Catenin 97
D12.776.930.137 BRCA1 Protein 101
D12.776.930.146 CDX2 Transcription Factor 3
D12.776.930.155 Core Binding Factors 3
D12.776.930.160 COUP Transcription Factors
D12.776.930.165 Cyclic AMP Receptor Protein 2
D12.776.930.211 E2F Transcription Factors 16
D12.776.930.213 Early Growth Response Transcription Factors 1
D12.776.930.215 Elongin
D12.776.930.216 Erythroid-Specific DNA-Binding Factors 1
D12.776.930.312 Fushi Tarazu Transcription Factors
D12.776.930.313 G-Box Binding Factors
D12.776.930.314 GATA Transcription Factors 2
D12.776.930.315 Goosecoid Protein 2
D12.776.930.317 Heat Shock Transcription Factors 1
D12.776.930.318 Hepatocyte Nuclear Factors 5
D12.776.930.320 Homeobox Protein PITX2
D12.776.930.321 Homeobox Protein Nkx-2.2
D12.776.930.324 Homeobox Protein Nkx-2.5 1
D12.776.930.325 Host Cell Factor C1 2
D12.776.930.326 I-kappa B Proteins 5
D12.776.930.327 Immunoglobulin J Recombination Signal Sequence-Binding Protein
D12.776.930.329 Inhibitor of Differentiation Proteins 2
D12.776.930.332 Interferon Regulatory Factors 11
D12.776.930.354 Interferon-Stimulated Gene Factor 3
D12.776.930.375 Kruppel-Like Transcription Factors 26
D12.776.930.386 Leucine-Responsive Regulatory Protein
D12.776.930.397 MADS Domain Proteins 3
D12.776.930.419 MDS1 and EVI1 Complex Locus Protein 2
D12.776.930.440 MSX1 Transcription Factor 8
D12.776.930.462 Myeloid Ecotropic Viral Integration Site 1 Protein 1
D12.776.930.483 Myeloid-Lymphoid Leukemia Protein 39
D12.776.930.542 Nanog Homeobox Protein 3
D12.776.930.600 NF-kappa B 218
D12.776.930.608 NFATC Transcription Factors 13
D12.776.930.612 NFI Transcription Factors 6
D12.776.930.616 Nuclear Factor 90 Proteins
D12.776.930.617 Nuclear Receptor Coactivators 6
D12.776.930.618 Nuclear Respiratory Factors
D12.776.930.640 Onecut Transcription Factors
D12.776.930.645 Orphan Nuclear Receptors 2
D12.776.930.650 Otx Transcription Factors 4
D12.776.930.680 p300-CBP Transcription Factors 5
D12.776.930.700 Paired Box Transcription Factors 21
D12.776.930.705 Peroxisome Proliferator-Activated Receptors 54
D12.776.930.710 POU Domain Factors 4
D12.776.930.712 Pre-B-Cell Leukemia Transcription Factor 1 2
D12.776.930.713 Promyelocytic Leukemia Protein 4
D12.776.930.714 B-Cell Lymphoma 3 Protein
D12.776.930.715 Proto-Oncogene Proteins c-bcl-6 3
D12.776.930.720 Proto-Oncogene Proteins c-ets 19
D12.776.930.725 Proto-Oncogene Proteins c-myb 30
D12.776.930.730 Proto-Oncogene Proteins c-rel 2
D12.776.930.760 Receptors, Aryl Hydrocarbon 133
D12.776.930.770 Receptors, Notch 20
D12.776.930.775 Receptors, Retinoic Acid 42
D12.776.930.778 Receptors, Steroid 143
D12.776.930.780 Repressor Proteins 189
D12.776.930.785 Rho Factor 12
D12.776.930.800 Sigma Factor 55
D12.776.930.806 Smad Proteins 14
D12.776.930.809 SMARCB1 Protein 15
D12.776.930.815 Snail Family Transcription Factors 4
D12.776.930.823 SOX Transcription Factors 1
D12.776.930.840 STAT Transcription Factors 23
D12.776.930.850 T-Box Domain Proteins 14
D12.776.930.875 TCF Transcription Factors 3
D12.776.930.882 TEA Domain Transcription Factors 3
D12.776.930.888 Thyroid Nuclear Factor 1
D12.776.930.900 Trans-Activators 110
D12.776.930.907 Transcription Factor AP-2 1
D12.776.930.908 Transcription Factor DP1 10
D12.776.930.919 Transcription Factor MTF-1
D12.776.930.930 Transcription Factors, General 1
D12.776.930.955 Transcriptional Elongation Factors 8
D12.776.930.960 Tristetraprolin 2
D12.776.930.969 Tumor Protein p73 6
D12.776.930.977 Winged-Helix Transcription Factors

PBX1 protein, human Chemical MeSH Browser

Pbx1 protein, mouse Chemical MeSH Browser

pbx1a protein, zebrafish Chemical MeSH Browser

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